26S Proteasome p48A Antibody (12A1): sc-65756

26S Proteasome p48A Antibody (12A1) is a mouse monoclonal IgG2a antibody that detects 26S proteasome p48A in human samples by western blotting (WB) and immunoprecipitation (IP). 26S proteasome p48A, also known as Rpt3 in yeast and S6 in humans, is a crucial component of the 19S regulatory complex of the 26S proteasome, which is essential for the degradation of ubiquitinated proteins. 26S proteasome p48A plays a vital role in maintaining cellular homeostasis by regulating the turnover of proteins involved in various biological processes, including cell cycle progression, apoptosis, and stress responses. 26S proteasome p48A is specifically involved in recognizing ubiquitinated substrates, facilitating their translocation into the 20S core for degradation, and is necessary for the recruitment of the p30 (Rpn12/S14) subunit of the 19S lid. Given its pivotal role in protein degradation and regulation, 26S proteasome p48A is a key player in cellular signaling pathways and has implications in various diseases, including cancer and neurodegenerative disorders. Anti-26S proteasome p48A antibody (12A1) is an invaluable tool for researchers studying proteasome function and its impact on cellular processes.

The preferred 26S Proteasome p48A antibody is 26S Proteasome p48A Antibody (1B8): sc-65749.