26S Proteasome p42A Antibody (123): sc-65750

26S Proteasome p42A Antibody (123) is a mouse monoclonal IgG1 kappa light chain antibody that detects 26S Proteasome p42A protein of Drosophila melanogaster origin by western blotting (WB) and immunoprecipitation (IP). Anti-26S Proteasome p42A antibody (123) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. 26S proteasome is a crucial multi-subunit complex responsible for degrading ubiquitinated proteins, a process vital for maintaining cellular homeostasis and regulating numerous biological pathways. This complex comprises over 30 distinct subunits, including 26S Proteasome p42A, also referred to as Rpn7 in yeast and S10 in humans. 26S Proteasome p42A is integral to stability and assembly of 19S regulatory complex, which plays a key role in recognizing ubiquitinated substrates, removing ubiquitin tags, and facilitating translocation into 20S core for degradation. 26S Proteasome p42A (123) monoclonal antibody supports research focused on proteostasis and cellular regulation, where proper functioning of 26S proteasome is essential for processes such as cell cycle regulation, apoptosis, and modulation of various signaling pathways.

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26S Proteasome p42A Antibody (123) References:

1. Linking the ubiquitin-proteasome pathway to chromatin remodeling/modification by nuclear receptors.  |  Kinyamu, HK., et al. 2005. J Mol Endocrinol. 34: 281-97. PMID: 15821097
2. Structural organization of the 19S proteasome lid: insights from MS of intact complexes.  |  Sharon, M., et al. 2006. PLoS Biol. 4: e267. PMID: 16869714
3. The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome.  |  Isono, E., et al. 2007. Mol Biol Cell. 18: 569-80. PMID: 17135287
4. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.  |  Wang, X., et al. 2007. Biochemistry. 46: 3553-65. PMID: 17323924
5. Ubiquitin dependent and independent protein degradation in the regulation of cellular polyamines.  |  Kahana, C. 2007. Amino Acids. 33: 225-30. PMID: 17404802
6. Aging perturbs 26S proteasome assembly in Drosophila melanogaster.  |  Vernace, VA., et al. 2007. FASEB J. 21: 2672-82. PMID: 17413001
7. beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint.  |  Li, X., et al. 2007. EMBO J. 26: 2339-49. PMID: 17431397
8. Rpn13p and Rpn14p are involved in the recognition of ubiquitinated Gcn4p by the 26S proteasome.  |  Seong, KM., et al. 2007. FEBS Lett. 581: 2567-73. PMID: 17499717
9. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein.  |  Kwak, MK., et al. 2007. Life Sci. 80: 2411-20. PMID: 17521679
10. Automated cryoelectron microscopy of 'single particles' applied to the 26S proteasome.  |  Nickell, S., et al. 2007. FEBS Lett. 581: 2751-6. PMID: 17531228
11. PSMD9 expression predicts radiotherapy response in breast cancer.  |  Langlands, FE., et al. 2014. Mol Cancer. 13: 73. PMID: 24673853
12. PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling.  |  Su, Y., et al. 2024. J Exp Clin Cancer Res. 43: 142. PMID: 38745188

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-26S Proteasome p42A Antibody (123) has 11 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

26S Proteasome p42A Antibody (123) Specifications

Alternate Product Name: 26S Proteasome p42A

Product Clone Name: 123

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: 26S Proteasome

Epitope Species: Drosophila melanogaster

Product Reactivity/Detection: p42A subunit of the 19S regulatory lid complex of the 26S Proteasome

Species Reactivity/Detection: d

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for 26S Proteasome p42A Antibody (123): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin