26S Proteasome p39A Antibody (50): sc-65754
- 26S Proteasome p39A Antibody (50) is a mouse monoclonal IgG1 κ 26S Proteasome p39A antibody, cited in 1 publications, provided at 200 µg/ml
- raised against 26S Proteasome purified from embryos of Drosophila melanogaster origin
- 26S Proteasome p39A Antibody (50) is recommended for detection of p39A subunit of the 19S regulatory base complex of the 26S Proteasome of d origin by WB and IP
- Anti-26S Proteasome p39A Antibody (50) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for 26S Proteasome p39A Antibody (50) for WB applications. These reagents are now offered in bundles with 26S Proteasome p39A Antibody (50) (see ordering information below).
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26S Proteasome p39A Antibody (50) is a mouse monoclonal IgG1 kappa light chain antibody that detects 26S Proteasome p39A of Drosophila melanogaster origin by western blotting (WB) and immunoprecipitation (IP). Anti-26S Proteasome p39A antibody (50) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. 26S proteasome is a crucial multi-subunit complex responsible for degrading ubiquitinated proteins, a process vital for maintaining cellular homeostasis and regulating numerous biological pathways, including cell cycle progression and stress responses. 26S proteasome consists of over 30 distinct subunits, with 26S Proteasome p39A, also known as Rpn9 in yeast and S11 in humans, being one of the non-ATPase lid subunits of the 19S regulatory complex. This subunit plays a significant role in proteasome assembly and stability, ensuring effective recognition and processing of ubiquitinated substrates. 19S regulatory complex identifies ubiquitin-tagged proteins, removes ubiquitin chains, and facilitates protein translocation into the 20S core for degradation. Proper functioning of 26S proteasome is critical for cellular health, as dysregulation can lead to various diseases, including cancer and neurodegenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
26S Proteasome p39A Antibody (50) References:
- The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme. | Hölzl, H., et al. 2000. J Cell Biol. 150: 119-30. PMID: 10893261
- Assembly of the Drosophila 26 S proteasome is accompanied by extensive subunit rearrangements. | Kurucz, E., et al. 2002. Biochem J. 365: 527-36. PMID: 11945175
- Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. | Ceriani, MF., et al. 2002. J Neurosci. 22: 9305-19. PMID: 12417656
- Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. | Park, Y., et al. 2005. Mol Cell Biol. 25: 3842-53. PMID: 15831487
- Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome. | Kiss, P., et al. 2005. Biochem J. 391: 301-10. PMID: 15946124
- The proteolytic function of the Arabidopsis 26S proteasome is required for specifying leaf adaxial identity. | Huang, W., et al. 2006. Plant Cell. 18: 2479-92. PMID: 17028202
- Aging perturbs 26S proteasome assembly in Drosophila melanogaster. | Vernace, VA., et al. 2007. FASEB J. 21: 2672-82. PMID: 17413001
- Rpn13p and Rpn14p are involved in the recognition of ubiquitinated Gcn4p by the 26S proteasome. | Seong, KM., et al. 2007. FEBS Lett. 581: 2567-73. PMID: 17499717
- Automated cryoelectron microscopy of 'single particles' applied to the 26S proteasome. | Nickell, S., et al. 2007. FEBS Lett. 581: 2751-6. PMID: 17531228
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
26S Proteasome p39A Antibody (50) | sc-65754 | 200 µg/ml | $322.00 | |||
26S Proteasome p39A Antibody (50): m-IgG Fc BP-HRP Bundle | sc-526965 | 200 µg Ab; 10 µg BP | $361.00 | |||
26S Proteasome p39A Antibody (50): m-IgG1 BP-HRP Bundle | sc-532338 | 200 µg Ab; 20 µg BP | $361.00 | |||
26S Proteasome p39A Antibody (50) AC | sc-65754 AC | 500 µg/ml, 25% agarose | $424.00 | |||
26S Proteasome p39A Antibody (50) HRP | sc-65754 HRP | 200 µg/ml | $322.00 | |||
26S Proteasome p39A Antibody (50) FITC | sc-65754 FITC | 200 µg/ml | $336.00 | |||
26S Proteasome p39A Antibody (50) PE | sc-65754 PE | 200 µg/ml | $349.00 | |||
26S Proteasome p39A Antibody (50) Alexa Fluor® 488 | sc-65754 AF488 | 200 µg/ml | $364.00 | |||
26S Proteasome p39A Antibody (50) Alexa Fluor® 546 | sc-65754 AF546 | 200 µg/ml | $364.00 | |||
26S Proteasome p39A Antibody (50) Alexa Fluor® 594 | sc-65754 AF594 | 200 µg/ml | $364.00 | |||
26S Proteasome p39A Antibody (50) Alexa Fluor® 647 | sc-65754 AF647 | 200 µg/ml | $364.00 | |||
26S Proteasome p39A Antibody (50) Alexa Fluor® 680 | sc-65754 AF680 | 200 µg/ml | $364.00 | |||
26S Proteasome p39A Antibody (50) Alexa Fluor® 790 | sc-65754 AF790 | 200 µg/ml | $364.00 |