20S Proteasome α2 Antibody (MCP21): sc-58413
- 20S Proteasome α2 Antibody (MCP21) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against placenta derived full length 20S Proteasome α2 of human origin
- recommended for detection of 20S Proteasome α2 (HC3) of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 20S Proteasome α2 Antibody (MCP21). This work is in progress.
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20S Proteasome α2 Antibody (MCP21) is a mouse monoclonal IgG1 antibody that detects 20S Proteasome α2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-20S Proteasome α2 antibody (MCP21) specifically targets a crucial component of the 26S proteasome, which plays a vital role in maintaining cellular homeostasis by degrading unnecessary or damaged proteins. The 20S proteasome core, where actual proteolytic activity occurs, is composed of a cylindrical structure formed by 28 subunits arranged in a specific order, with α subunits serving as structural components that regulate access to catalytic β subunits housed within. This structural organization ensures that only properly tagged proteins enter the catalytic chamber for degradation, thereby preventing accumulation of potentially harmful proteins that could disrupt cellular function. Precise regulation of protein degradation by the proteasome is critical for various cellular processes, including cell cycle, apoptosis, and responses to oxidative stress, making the study of 20S proteasome α2 and its interactions vital for understanding numerous biological pathways and disease mechanisms.
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20S Proteasome α2 Antibody (MCP21) References:
- Evaluation of Zinc-α-2-Glycoprotein and Proteasome Subunit β-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology. | O'Hurley, G., et al. 2010. Appl Immunohistochem Mol Morphol. 18: 512-7. PMID: 20661134
- Comprehensively Analyzed Macrophage-Regulated Genes Indicate That PSMA2 Promotes Colorectal Cancer Progression. | Qi, J., et al. 2020. Front Oncol. 10: 618902. PMID: 33537240
- Increased co-expression of PSMA2 and GLP-1 receptor in cervical cancer models in type 2 diabetes attenuated by Exendin-4: A translational case-control study. | Mao, D., et al. 2021. EBioMedicine. 65: 103242. PMID: 33684886
- Influenza A Virus Uses PSMA2 for Downregulation of the NRF2-Mediated Oxidative Stress Response. | Rashid, MU., et al. 2022. J Virol. 96: e0199021. PMID: 35019712
- PSMA2 knockdown impacts expression of proteins involved in immune and cellular stress responses in human lung cells. | Rashid, MU., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166617. PMID: 36481484
- HLA-A, HSPA5, IGFBP5 and PSMA2 Are Restriction Factors for Zika Virus Growth in Astrocytic Cells. | Sher, AA., et al. 2022. Viruses. 15: PMID: 36680137
- A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing. | Sahu, I., et al. 2023. Biomolecules. 13: PMID: 36979414
- RNAi-based silencing of proteasome 20S subunit alpha 2 affected the survival and development of Henosepilachna vigintioctopunctata. | Liu, J., et al. 2023. Pestic Biochem Physiol. 195: 105547. PMID: 37666590
- PSMA2 promotes glioma proliferation and migration via EMT. | Zhang, Y., et al. 2024. Pathol Res Pract. 256: 155278. PMID: 38574629
- Corynoline protects chronic pancreatitis via binding to PSMA2 and alleviating pancreatic fibrosis. | Wang, P., et al. 2024. J Gastroenterol. 59: 1037-1051. PMID: 39145797
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20S Proteasome α2 Antibody (MCP21) | sc-58413 | 50 µg/0.5 ml | $316.00 |