20S Proteasome α1 Antibody (C-7): sc-166073

20S Proteasome α1 Antibody (C-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects PSMA1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PSMA1 antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMA1 plays a crucial role in the ubiquitin-proteasome pathway, maintaining cellular homeostasis by regulating degradation of misfolded or damaged proteins. This process is vital for various cellular functions, including cell cycle regulation, signal transduction, and modulation of transcription factors. PSMA1 is part of a core particle made up of 28 subunits arranged in a cylindrical structure, allowing efficient processing of ubiquitinated substrates. Proper functioning of PSMA1 is critical, as dysregulation can lead to various diseases, including cancer and neurodegenerative disorders. PSMA1 monoclonal antibody (C-7) enables researchers to gain insights into protein degradation dynamics and their implications in health and disease.

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20S Proteasome α1 Antibody (C-7) References:

1. Species variation in ATP-dependent protein degradation: protease profiles differ between mycobacteria and protease functions differ between Mycobacterium smegmatis and Escherichia coli.  |  Knipfer, N., et al. 1999. Gene. 231: 95-104. PMID: 10231573
2. Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.  |  Whitehouse, AS., et al. 2001. Cancer Res. 61: 3604-9. PMID: 11325828
3. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.  |  Touitou, R., et al. 2001. EMBO J. 20: 2367-75. PMID: 11350925
4. Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation.  |  Whitehouse, AS. and Tisdale, MJ. 2001. Biochem Biophys Res Commun. 285: 598-602. PMID: 11453634
5. Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes.  |  Silva Pereira, I., et al. 1992. Gene. 120: 235-42. PMID: 1398136
6. The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation.  |  Higashitsuji, H., et al. 2005. Cell Cycle. 4: 1335-7. PMID: 16177571
7. The N-terminal penultimate residue of 20S proteasome alpha1 influences its N(alpha) acetylation and protein levels as well as growth rate and stress responses of Haloferax volcanii.  |  Humbard, MA., et al. 2009. J Bacteriol. 191: 3794-803. PMID: 19376868
8. The Contribution of the 20S Proteasome to Proteostasis.  |  Kumar Deshmukh, F., et al. 2019. Biomolecules. 9: PMID: 31100951
9. Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeast.  |  Howell, LA., et al. 2019. Sci Rep. 9: 12418. PMID: 31455793
10. The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family.  |  Bey, F., et al. 1993. Mol Gen Genet. 237: 193-205. PMID: 7681138
11. Human proteasome subunits from 2-dimensional gels identified by partial sequencing.  |  Kristensen, P., et al. 1994. Biochem Biophys Res Commun. 205: 1785-9. PMID: 7811265
12. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit.  |  Zaiss, D. and Belote, JM. 1997. Gene. 201: 99-105. PMID: 9409776

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-20S Proteasome α1 Antibody (C-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-20S Proteasome α1 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

20S Proteasome α1 Antibody (C-7) Specifications

Alternate Product Name: 20S Proteasome α1

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 131-225

Epitope Target: 20S Proteasome α1

Epitope Species: human

Product Reactivity/Detection: 20S Proteasome α1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for 20S Proteasome α1 Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin