Molecular structure of 2-Oleoylglycerol, CAS Number: 3443-84-3
2-Oleoylglycerol (CAS 3443-84-3)
See product citations (2)
Alternate Names:
2-Monoolein
Application:
2-Oleoylglycerol is a GPR119 agonist that regulates GLP-1 release
CAS Number:
3443-84-3
Purity:
≥95%
Molecular Weight:
356.54
Molecular Formula:
C21H40O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Oleoylglycerol is a GPR119 agonist that regulates GLP-1 release. 2-Oleoylglycerol is derived from trioleoylglycerol through the action of pancreatic lipase (PL). It serves as a valuable model for exploring the properties and behavior of lipid bilayers, as well as for investigating the interplay between lipids and proteins. Furthermore, it finds utility as a substrate in the examination of enzyme kinetics and as a medium for cell culture and in vitro assays.
2-Oleoylglycerol (CAS 3443-84-3) References
- Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. | Ghafouri, N., et al. 2004. Br J Pharmacol. 143: 774-84. PMID: 15492019
- Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. | Fowler, CJ. and Tiger, G. 2005. Biochem Pharmacol. 69: 1241-5. PMID: 15794945
- Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. | Vandevoorde, S., et al. 2007. Br J Pharmacol. 150: 186-91. PMID: 17143303
- Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. | Hanlon, EC., et al. 2015. J Clin Endocrinol Metab. 100: 220-6. PMID: 25368979
- Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol. | Murataeva, N., et al. 2016. Pharmacol Res. 110: 173-180. PMID: 27117667
- Evolution of the diacylglycerol lipases. | Yuan, D., et al. 2016. Prog Lipid Res. 64: 85-97. PMID: 27568643
- Synthesis of 1,3-distearoyl-2-oleoylglycerol by enzymatic acidolysis in a solvent-free system. | Wang, X., et al. 2017. Food Chem. 228: 420-426. PMID: 28317743
- Endocannabinoid and Opioid System Interactions in Exercise-Induced Hypoalgesia. | Crombie, KM., et al. 2018. Pain Med. 19: 118-123. PMID: 28387833
- Olfactory connectivity mediates sleep-dependent food choices in humans. | Bhutani, S., et al. 2019. Elife. 8: PMID: 31591965
- Neuroprotective Effect of 1,3-dipalmitoyl-2-oleoylglycerol Derived from Rice Bran Oil against Cerebral Ischemia-Reperfusion Injury in Rats. | Lee, HK., et al. 2022. Nutrients. 14: PMID: 35405992
- Oxidative lipidomics to elucidate the non-volatile derivatives of four typical triglycerides in vegetable oils under simulated frying conditions. | Hu, Q., et al. 2023. Food Chem. 410: 135414. PMID: 36638631
- Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol. | Yang, M., et al. 2023. Nat Commun. 14: 228. PMID: 36646715
- 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | Sugiura, T., et al. 1996. Biochem Biophys Res Commun. 229: 58-64. PMID: 8954083
Activator of:
GPR119, and Pancreatic Lipase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Oleoylglycerol, 1 mg | sc-213888 | 1 mg | $52.00 | |||
2-Oleoylglycerol, 5 mg | sc-213888B | 5 mg | $173.00 | |||
2-Oleoylglycerol, 10 mg | sc-213888A | 10 mg | $316.00 |