17-DMAP-GA
Application:
17-DMAP-GA is a water-soluble analog of geldanamycin and inhibitor of HSP90
Molecular Weight:
631
Molecular Formula:
C33H50N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
17-DMAP-GA belongs to a set of geldanamycin analogs that have been synthesized based on binding affinity to Hsp90 and water solubility. 17-DMAP-GA was shown to greatly inhibit the growth of cancer cells (IC50 below 100 nM). Its binding affinity to Hsp90 was not significantly affected while its water solubility was highly improved compared to 17-AAG.
17-DMAP-GA References
- Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. | Tian, ZQ., et al. 2004. Bioorg Med Chem. 12: 5317-29. PMID: 15388159
- Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1. | Huang, Y., et al. 2007. Pharm Res. 24: 1702-12. PMID: 17457659
- Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. | Liu, R., et al. 2007. Mol Pharmacol. 72: 1637-46. PMID: 17875604
- Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins. | Pham, AN., et al. 2009. Pharm Res. 26: 936-45. PMID: 19067123
- Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor. | Jurczyszyn, A., et al. 2014. J Cancer. 5: 480-90. PMID: 24959301
- Effect of heat stress and Hsp90 inhibition on T-type calcium currents and voltage-dependent potassium currents in leydig cells. | Tenorio, BM., et al. 2019. J Therm Biol. 84: 1-7. PMID: 31466741
Inhibitor of:
HSP 90.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17-DMAP-GA, 1 mg | sc-364390 | 1 mg | $263.00 | |||
17-DMAP-GA, 5 mg | sc-364390A | 5 mg | $681.00 |