Molecular structure of 17-AEP-GA
17-AEP-GA
Application:
17-AEP-GA is a new, less cytotoxic geldanamycin (GA) analog and inhibitor of HSP90
Molecular Weight:
643
Molecular Formula:
C34H50N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
17-AEP-GA is a geldanamycin (GA) analog with an alkylamino group in place of the methoxy moiety at C17. 17-AEP-GA is less cytotoxic than GA and remains biologically active. 17-AEP-GA was shown to induce similar tumor cell growth inhibition to geldanamycin. Unlike 17-AAG which is soluble in DMSO, 17-AEP-GA is water soluble.
17-AEP-GA References
- Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. | Tian, ZQ., et al. 2004. Bioorg Med Chem. 12: 5317-29. PMID: 15388159
- Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. | Liu, R., et al. 2007. Mol Pharmacol. 72: 1637-46. PMID: 17875604
- High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-(pyrrolidin-1-yl)ethyl]-aminno-17-demethoxygeldanamycin. | Lukasiewicz, E., et al. 2009. J Physiol Pharmacol. 60: 161-6. PMID: 19826195
- 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. | Miekus, K., et al. 2012. Oncol Rep. 28: 1903-9. PMID: 22941268
- Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. | Pizarro, JC., et al. 2013. PLoS Negl Trop Dis. 7: e2492. PMID: 24147171
- HSP90 affects the stability of BMAL1 and circadian gene expression. | Schneider, R., et al. 2014. J Biol Rhythms. 29: 87-96. PMID: 24682203
- In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non‑water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines. | Ghadban, T., et al. 2016. Int J Mol Med. 38: 1296-302. PMID: 27498942
- The Role of the Heat-Shock Proteins in Esophagogastric Cancer. | Tustumi, F., et al. 2022. Cells. 11: PMID: 36078072
- Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules. | Tassone, G., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36355513
- The role of NQO1 in the metabolism of benzoquinone ansamycin Hsp90 inhibitors and development of novel Hsp90 inhibitors as anticancer agents. | Guo, Wenchang. (2008): ASSAY and Drug Development Technologies. 6.4: 601-602.
Inhibitor of:
HSP 90.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17-AEP-GA, 1 mg | sc-364389 | 1 mg | $263.00 | |||
17-AEP-GA, 5 mg | sc-364389A | 5 mg | $681.00 |