Date published: 2026-4-24

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15(R)-Prostaglandin D2 (CAS 59894-05-2)

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Alternate Names:
9α,15R-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
Application:
15(R)-Prostaglandin D2 is a surprisingly potent agonist at the DP2 receptor
CAS Number:
59894-05-2
Molecular Weight:
352.5
Molecular Formula:
C20H32O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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15(R)-Prostaglandin D2 is a compound that plays a significant role in immunological and inflammatory research. It is one of the isomers of prostaglandin D2 (PGD2) and is involved in the study of lipid mediators and their biological functions. Researchers use 15(R)-Prostaglandin D2 to understand its interactions with prostaglandin receptors, which can lead to various physiological responses. This compound is also instrumental in exploring the resolution phase of inflammation, as it may be involved in the transition from pro-inflammatory to anti-inflammatory signaling pathways. The study of 15(R)-Prostaglandin D2 is for elucidating the mechanisms of action of lipid mediators in the context of allergic responses, as well as in the regulation of sleep-wake cycles. Additionally, it serves as an analytical standard in the quantification of prostaglandin levels within biological samples, aiding in the assessment of their roles in different physiological and pathological states.


15(R)-Prostaglandin D2 (CAS 59894-05-2) References

  1. Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.  |  Trivedi, SG., et al. 2006. Proc Natl Acad Sci U S A. 103: 5179-84. PMID: 16547141
  2. Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils.  |  Cossette, C., et al. 2007. J Pharmacol Exp Ther. 320: 173-9. PMID: 17041009
  3. Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy.  |  Diers, AR., et al. 2010. Biochem J. 430: 69-78. PMID: 20536428
  4. LC/MS/MS method for analysis of E₂ series prostaglandins and isoprostanes.  |  Brose, SA., et al. 2011. J Lipid Res. 52: 850-9. PMID: 21317107
  5. A fast one-step extraction and UPLC-MS/MS analysis for E2/D 2 series prostaglandins and isoprostanes.  |  Brose, SA., et al. 2013. Lipids. 48: 411-9. PMID: 23400687
  6. Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents.  |  Zhang, S., et al. 2013. Am J Physiol Gastrointest Liver Physiol. 304: G908-16. PMID: 23471341
  7. Prostaglandin D2 receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus.  |  Zhang, S., et al. 2014. Dis Esophagus. 27: 601-6. PMID: 24165271
  8. Modern Methods of Sample Preparation for the Analysis of Oxylipins in Biological Samples.  |  Liakh, I., et al. 2019. Molecules. 24: PMID: 31027298
  9. Molecular cloning and characterization of the human prostanoid DP receptor.  |  Boie, Y., et al. 1995. J Biol Chem. 270: 18910-6. PMID: 7642548

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

15(R)-Prostaglandin D2, 1 mg

sc-220629
1 mg
$120.00

15(R)-Prostaglandin D2, 5 mg

sc-220629A
5 mg
$540.00