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1-Deoxynojirimycin Hydrochloride (CAS 73285-50-4)

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Alternate Names:
Moranoline Hydrochloride; 1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride
Application:
1-Deoxynojirimycin Hydrochloride is a glucose analog and glucosidase I and II inhibitor
CAS Number:
73285-50-4
Purity:
≥95%
Molecular Weight:
199.63
Molecular Formula:
C6H13NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Deoxynojirimycin Hydrochloride, a chemical compound, has been a significant focus of scientific research, particularly in the fields of carbohydrate chemistry and enzyme inhibition. In research, this compound has been extensively studied for its inhibitory effects on glycosidase enzymes. Glycosidases play crucial roles in carbohydrate metabolism by catalyzing the hydrolysis of glycosidic bonds. 1-Deoxynojirimycin Hydrochloride acts as a potent inhibitor of specific glycosidases, such as α-glucosidase and α-galactosidase, by binding to their active sites and preventing substrate hydrolysis. This inhibition mechanism makes it a valuable tool for studying glycoside hydrolysis pathways and the role of glycosidases in biological processes. Moreover, 1-Deoxynojirimycin Hydrochloride has been investigated for its potential applications in the treatment of lysosomal storage disorders and viral infections. By inhibiting glycosidase enzymes involved in glycoprotein processing, this compound has shown promise in reducing the accumulation of abnormal glycoproteins in lysosomes and modulating viral glycoprotein maturation. Research in this area aims to explain the molecular mechanisms underlying its effects and explore its potential as a lead compound for further research. Furthermore, 1-Deoxynojirimycin Hydrochloride has been utilized as a molecular probe in studies of carbohydrate metabolism and glycosylation pathways. Its use in enzyme assays and biochemical studies has provided insights into the substrate specificity and catalytic mechanisms of glycosidase enzymes, facilitating the discovery of novel enzyme inhibitors and research strategies.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1-Deoxynojirimycin Hydrochloride (CAS 73285-50-4) References

  1. The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.  |  Papandréou, MJ., et al. 2002. Mol Pharmacol. 61: 186-93. PMID: 11752220
  2. Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry.  |  Nuengchamnong, N., et al. 2007. J Pharm Biomed Anal. 44: 853-8. PMID: 17512690
  3. Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors.  |  Ma, CM., et al. 2008. J Med Chem. 51: 6188-94. PMID: 18783210
  4. Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver.  |  Tsuduki, T., et al. 2009. J Agric Food Chem. 57: 11024-9. PMID: 19863049
  5. Optimization of 1-deoxynojirimycin extraction from mulberry leaves by using response surface methodology.  |  Vichasilp, C., et al. 2009. Biosci Biotechnol Biochem. 73: 2684-9. PMID: 19966480
  6. The pharmacological chaperone AT2220 increases recombinant human acid α-glucosidase uptake and glycogen reduction in a mouse model of Pompe disease.  |  Khanna, R., et al. 2012. PLoS One. 7: e40776. PMID: 22815812
  7. Hypoxia modulates A431 cellular pathways association to tumor radioresistance and enhanced migration revealed by comprehensive proteomic and functional studies.  |  Ren, Y., et al. 2013. Mol Cell Proteomics. 12: 485-98. PMID: 23204318
  8. The pharmacological chaperone AT2220 increases the specific activity and lysosomal delivery of mutant acid alpha-glucosidase, and promotes glycogen reduction in a transgenic mouse model of Pompe disease.  |  Khanna, R., et al. 2014. PLoS One. 9: e102092. PMID: 25036864
  9. Effect of solar radiation on the functional components of mulberry (Morus alba L.) leaves.  |  Sugiyama, M., et al. 2016. J Sci Food Agric. 96: 3915-21. PMID: 26756109
  10. Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases.  |  Saunier, B., et al. 1982. J Biol Chem. 257: 14155-61. PMID: 6216253

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Deoxynojirimycin Hydrochloride, 1 mg

sc-201694
1 mg
$73.00

1-Deoxynojirimycin Hydrochloride, 10 mg

sc-201694A
10 mg
$150.00

1-Deoxynojirimycin Hydrochloride, 100 mg

sc-201694B
100 mg
$420.00