Molecular structure of 1,2,4-Triazole, CAS Number: 288-88-0
1,2,4-Triazole (CAS 288-88-0)
Alternate Names:
Pyrrodiazole
Application:
1,2,4-Triazole is A chemical present in a variety of fungicides
CAS Number:
288-88-0
Molecular Weight:
69.07
Molecular Formula:
C2H3N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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1,2,4-Triazole is a versatile organic compound widely employed in both the synthesis of organic compounds and various scientific research applications. This five-membered heterocyclic compound features a central nitrogen atom within its ring structure, making it a valuable building block for organic synthesis due to its capacity to form robust bonds with other organic molecules. 1,2,4-Triazole is postulated to function as an enzyme inhibitor, notably affecting enzymes like cytochrome P450. Additionally, it has been observed to interact with various proteins, including DNA polymerase.
1,2,4-Triazole (CAS 288-88-0) References
- The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist. | Moulin, A., et al. 2013. Amino Acids. 44: 301-14. PMID: 22798076
- 5-[(E)-Meth-oxy(phen-yl)methyl-idene]-1,3,4-triphenyl-4,5-dihydro-1H-1,2,4-triazole. | Maji, B., et al. 2012. Acta Crystallogr Sect E Struct Rep Online. 68: o3307. PMID: 23468812
- Synthesis, characterization of 1,2,4-triazole Schiff base derived 3d-metal complexes: Induces cytotoxicity in HepG2, MCF-7 cell line, BSA binding fluorescence and DFT study. | Tyagi, P., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 171: 246-257. PMID: 27541797
- Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties. | Szulczyk, D., et al. 2017. Molecules. 22: PMID: 28272311
- 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. | Thakkar, SS., et al. 2017. Bioorg Med Chem. 25: 4064-4075. PMID: 28634040
- New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells. | Ahmed, FF., et al. 2018. Eur J Med Chem. 151: 705-722. PMID: 29660690
- Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative. | Jiang, GW., et al. 2020. J Int Med Res. 48: 300060520903874. PMID: 32043396
- Evaluation of Biological Activity of Derivatives of 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and 1,2,4-Triazole. | Doshi, GM., et al. 2021. Endocr Metab Immune Disord Drug Targets. 21: 905-911. PMID: 32729435
- New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies. | Stingaci, E., et al. 2020. Bioorg Med Chem Lett. 30: 127368. PMID: 32738986
- Novel 1,2,4-triazole derivatives: Design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies. | Turky, A., et al. 2020. Arch Pharm (Weinheim). 353: e2000170. PMID: 32893368
- Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds. | Grytsai, O., et al. 2020. Bioorg Chem. 104: 104271. PMID: 32992279
- An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action. | Wang, Y. and Liu, D. 2022. Drug Res (Stuttg). 72: 131-138. PMID: 34758502
- Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages. | Hamoud, MMS., et al. 2022. Bioorg Chem. 124: 105808. PMID: 35447409
- Synthesis and Biological Activity Evaluation of Pyrazole-1,2,4-triazole Hybrids: A Computer-aided Docking Studies. | Mallisetty, NM., et al. 2023. Curr Drug Discov Technol. 20: e251122211263. PMID: 36437730
- Design, synthesis, and biological evaluation of pleuromutilin derivatives containing 1,2,4-triazole linker. | Zhou, ZD., et al. 2023. Drug Dev Res. 84: 703-717. PMID: 36896715
Inhibitor of:
LOXL2, and ZNF654.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2,4-Triazole, 25 g | sc-253972 | 25 g | $35.00 | |||
1,2,4-Triazole, 100 g | sc-253972A | 100 g | $115.00 |