TSC-36 Antibody (JJ7): sc-80408

TSC-36 Antibody (JJ7) is a rat monoclonal IgG2b antibody that detects TSC-36 protein of mouse, rat, and human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-TSC-36 antibody (JJ7) is available as the non-conjugated format. TSC-36, also known as TGF-b1-stimulated clone 36 or follistatin-related protein 1, is a secreted extracellular glycoprotein that plays a crucial role in cellular growth regulation. TSC-36 shares amino acid sequence similarities with follistatin, an important inhibitor of activin, due to the presence of a follistatin module. TSC-36 is a heparin-binding protein, which suggests involvement in various biological processes, including cell signaling and tissue remodeling. TSC-36 expression is induced in response to transforming growth factor beta 1 (TGF-b1), highlighting significance in the negative regulation of cellular proliferation. TSC-36 is absent in small cell lung cancer cells, which are known for their aggressive nature, while detected in some non-small cell lung cancer cells, indicating a potential role in tumor biology and providing insights into function as a biomarker for cancer progression.

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TSC-36 Antibody (JJ7) References:

1. Expression of a TGF-beta1 inducible gene, Tsc-36, causes growth inhibition in human lung cancer cell lines.  |  Sumitomo, K., et al. 2000. Cancer Lett. 155: 37-46. PMID: 10814877
2. Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, Tsc-36, inhibits invasion.  |  Johnston, IM., et al. 2000. Oncogene. 19: 5348-58. PMID: 11103936
3. Potential preventive effects of follistatin-related protein/Tsc-36 on joint destruction and antagonistic modulation of its autoantibodies in rheumatoid arthritis.  |  Tanaka, M., et al. 2003. Int Immunol. 15: 71-7. PMID: 12502727
4. Structural characterization of Tsc-36/Flik: analysis of two charge isoforms.  |  Hambrock, HO., et al. 2004. J Biol Chem. 279: 11727-35. PMID: 14701841
5. Ameliorative effects of follistatin-related protein/Tsc-36/FSTL1 on joint inflammation in a mouse model of arthritis.  |  Kawabata, D., et al. 2004. Arthritis Rheum. 50: 660-8. PMID: 14872511
6. Tsc-36/FRP inhibits vascular smooth muscle cell proliferation and migration.  |  Liu, S., et al. 2006. Exp Mol Pathol. 80: 132-40. PMID: 16256108
7. Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide.  |  Shibanuma, M., et al. 1993. Eur J Biochem. 217: 13-9. PMID: 7901004
8. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue.  |  Zwijsen, A., et al. 1994. Eur J Biochem. 225: 937-46. PMID: 7957230
9. Decrease in the expression of a novel TGF beta1-inducible and ras-recision gene, Tsc-36, in human cancer cells.  |  Mashimo, J., et al. 1997. Cancer Lett. 113: 213-9. PMID: 9065824
10. Tsc-36 (follistatin-related polypeptide) gene expression in estrogen receptor positive osteoblastic cell line, CDO7F.  |  Ohashi, T., et al. 1997. Calcif Tissue Int. 61: 400-3. PMID: 9351882
11. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases.  |  Tanaka, M., et al. 1998. Int Immunol. 10: 1305-14. PMID: 9786430
12. cDNA cloning and distribution of the Xenopus follistatin-related protein.  |  Okabayashi, K., et al. 1999. Biochem Biophys Res Commun. 254: 42-8. PMID: 9920730

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TSC-36 Antibody (JJ7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TSC-36 Antibody (JJ7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TSC-36 Antibody (JJ7) Specifications

Alternate Product Name: TSC-36

Product Clone Name: JJ7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: TSC-36

Epitope Species: human

Product Reactivity/Detection: TSC-36

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TSC-36 Antibody (JJ7): N/A