TIP120A Antibody (B-8): sc-137124
- TIP120A Antibody (B-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 396-480 of TIP120A of human origin
- recommended for detection of TIP120A of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-137124 X, 200 µg/0.1 ml)
- m-IgG1 BP-HRP is the preferred secondary detection reagent for TIP120A Antibody (B-8) for WB applications. This reagent is now offered in a bundle with TIP120A Antibody (B-8) (see ordering information below).
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TIP120A Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects TIP120A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIP120A is a crucial protein that plays a significant role in transcriptional regulation by forming complexes with TATA-binding protein (TBP) and various nuclear proteins, thereby facilitating preinitiation complex assembly necessary for gene expression. TIP120A is ubiquitously expressed and particularly important because TIP120A directly interacts with TBP and a specific subunit of RNA polymerases, which enhances RNA polymerase II integration into transcription machinery. TIP120A′s ability to act as a global activator in transcriptional regulation underscores TIP120A′s importance in controlling multiple gene expression amplification, making TIP120A a vital component in cellular process regulation. TIP120A′s chaperone-like activity towards RNA polymerases further emphasizes TIP120A′s role in ensuring proper transcriptional apparatus functioning, which is essential for maintaining cellular homeostasis and responding to various physiological signals.
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TIP120A Antibody (B-8) References:
- TIP120A associates with cullins and modulates ubiquitin ligase activity. | Min, KW., et al. 2003. J Biol Chem. 278: 15905-10. PMID: 12609982
- Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. | Oshikawa, K., et al. 2003. Biochem Biophys Res Commun. 303: 1209-16. PMID: 12684064
- TIP120A associates with unneddylated cullin 1 and regulates its neddylation. | Hwang, JW., et al. 2003. FEBS Lett. 541: 102-8. PMID: 12706828
- Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo. | Chua, YS., et al. 2011. PLoS One. 6: e16071. PMID: 21249194
- CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis. | Dubiel, D., et al. 2013. Biochim Biophys Acta. 1833: 1078-84. PMID: 23328082
- Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. | Liu, X., et al. 2018. Mol Cell. 69: 773-786.e6. PMID: 29499133
- Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells. | Che, Z., et al. 2018. Am J Transl Res. 10: 1357-1372. PMID: 29887951
- CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. | Kajiho, H., et al. 2019. Sci Rep. 9: 13152. PMID: 31511573
- Bioinformatics Analysis of the Prognostic Significance of CAND1 in ERα-Positive Breast Cancer. | Alhammad, R. 2022. Diagnostics (Basel). 12: PMID: 36292029
- ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3. | Ao, YQ., et al. 2023. J Immunother Cancer. 11: PMID: 38148115
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIP120A Antibody (B-8) | sc-137124 | 200 µg/ml | $322.00 | |||
TIP120A Antibody (B-8): m-IgG1 BP-HRP Bundle | sc-542650 | 200 µg Ab; 20 µg BP | $361.00 | |||
TIP120A Antibody (B-8) X | sc-137124 X | 200 µg/0.1 ml | $322.00 |