Synaptoporin Antibody (C-9): sc-376761
- Synaptoporin Antibody (C-9) is a mouse monoclonal IgG2a κ Synaptoporin antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 189-223 within an internal region of Synaptoporin of human origin
- Synaptoporin Antibody (C-9) is recommended for detection of Synaptoporin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and porcine
- Anti-Synaptoporin Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Synaptoporin Antibody (C-9) for WB and IHC(P) applications. These reagents are now offered in bundles with Synaptoporin Antibody (C-9) (see ordering information below).
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Synaptoporin Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects Synaptoporin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Synaptoporin antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Synaptoporin, also known as synaptophysin 2, plays a crucial role in synaptic vesicle recycling, which is essential for neurotransmitter release and communication between neurons. Located in the membrane of small synaptic vesicles, Synaptoporin is a member of the synaptophysin/synaptobrevin family and shares high homology with Synaptophysin 1. Both proteins feature four transmembrane domains and a short cytoplasmic tail, which is significant for their function in vesicle formation and trafficking. Additionally, Synaptoporin contains a MARVEL domain, a membrane-associating domain that is important for lipid interactions, and exhibits calcium-binding activity that may be localized to its cytoplasmic tail. This calcium-binding capability is vital for the regulation of synaptic vesicle dynamics, as Synaptoporin influences the interaction with other proteins such as syntaphilin and synaptophysin, which together modulate the assembly and secretion of synaptic vesicles.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Synaptoporin Antibody (C-9) References:
- Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons. | Singec, I., et al. 2002. J Comp Neurol. 452: 139-53. PMID: 12271488
- Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein. | Dai, J., et al. 2003. Mol Biol Rep. 30: 185-91. PMID: 12974474
- Heterogeneous expression of the cholecystokinin-like immunoreactivity in the mouse hippocampus, with special reference to the dorsoventral difference. | Jinno, S. and Kosaka, T. 2003. Neuroscience. 122: 869-84. PMID: 14643757
- Differential expression pattern and steroid hormone sensitivity of SNAP-25 and synaptoporin mRNA in the telencephalic song control nucleus HVC of the zebra finch. | Voigt, C., et al. 2004. J Comp Neurol. 475: 83-94. PMID: 15176086
- Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA. | Leube, RE., et al. 1987. EMBO J. 6: 3261-8. PMID: 3123215
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synaptoporin Antibody (C-9) | sc-376761 | 200 µg/ml | $322.00 | |||
Synaptoporin Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-529930 | 200 µg Ab; 10 µg BP | $361.00 | |||
Synaptoporin Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-523085 | 200 µg Ab, 40 µg BP | $361.00 | |||
Synaptoporin Antibody (C-9): m-IgG2a BP-HRP Bundle | sc-547403 | 200 µg Ab; 10 µg BP | $361.00 | |||
Synaptoporin Antibody (C-9) AC | sc-376761 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Synaptoporin Antibody (C-9) HRP | sc-376761 HRP | 200 µg/ml | $322.00 | |||
Synaptoporin Antibody (C-9) FITC | sc-376761 FITC | 200 µg/ml | $336.00 | |||
Synaptoporin Antibody (C-9) PE | sc-376761 PE | 200 µg/ml | $349.00 | |||
Synaptoporin Antibody (C-9) Alexa Fluor® 488 | sc-376761 AF488 | 200 µg/ml | $364.00 | |||
Synaptoporin Antibody (C-9) Alexa Fluor® 546 | sc-376761 AF546 | 200 µg/ml | $364.00 | |||
Synaptoporin Antibody (C-9) Alexa Fluor® 594 | sc-376761 AF594 | 200 µg/ml | $364.00 | |||
Synaptoporin Antibody (C-9) Alexa Fluor® 647 | sc-376761 AF647 | 200 µg/ml | $364.00 | |||
Synaptoporin Antibody (C-9) Alexa Fluor® 680 | sc-376761 AF680 | 200 µg/ml | $364.00 | |||
Synaptoporin Antibody (C-9) Alexa Fluor® 790 | sc-376761 AF790 | 200 µg/ml | $364.00 | |||
Synaptoporin (C-9) Neutralizing Peptide | sc-376761 P | 100 µg/0.5 ml | $69.00 |