RhebL1 Antibody (A-2): sc-515057

RhebL1 Antibody (A-2) is a mouse monoclonal IgG1 antibody that detects RhebL1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RhebL1, also known as ras homolog enriched in brain-like protein 1 or GTPase RhebL1, is a 183 amino acid protein that plays a crucial role in cellular signaling pathways by regulating the activity of Rictor, a key component of the mTOR signaling pathway. This regulation is vital for various cellular processes, including growth, proliferation, and survival, making RhebL1 an important player in cancer biology, as RhebL1 expression is often upregulated in tumor cell lines. RhebL1 is localized to both the cell membrane and the cytoplasm, which is significant for function in signal transduction. RhebL1 exists in two alternatively spliced isoforms and is encoded by a gene located on human chromosome 12q13.12, a region associated with several genetic disorders. RhebL1′s ability to activate NFκB-mediated gene transcription further underscores importance in modulating immune responses and inflammation. With diverse roles in cellular signaling and disease, RhebL1 is a valuable target for research and therapeutic applications, making anti-RhebL1 antibody (A-2) an essential tool for scientists studying these critical biological processes.

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RhebL1 Antibody (A-2) References:

1. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.  |  Tee, AR., et al. 2005. FEBS Lett. 579: 4763-8. PMID: 16098514
2. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B.  |  Yuan, J., et al. 2005. Mol Biol Rep. 32: 205-14. PMID: 16328882
3. Effects of RhebL1 silencing on the mTOR pathway.  |  Bonneau, A. and Parmar, N. 2012. Mol Biol Rep. 39: 2129-37. PMID: 21655954
4. DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia.  |  Masetti, R., et al. 2013. Oncotarget. 4: 1712-20. PMID: 24127550
5. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.  |  Sato, T., et al. 2015. J Biol Chem. 290: 1096-105. PMID: 25422319
6. Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.  |  Kim, HJ., et al. 2017. Oncotarget. 8: 20851-20864. PMID: 28209923
7. A pediatric case of acute megakaryocytic leukemia with double chimeric transcripts of CBFA2T3-GLIS2 and DHH-RHEBL1.  |  Mitsui-Sekinaka, K., et al. 2018. Leuk Lymphoma. 59: 1511-1513. PMID: 29043865
8. Host Cell-dependent Modulatory Role of Ras Homolog Enriched in Brain-Like-1 (RhebL1) Protein in Influenza A/NWS/33 Virus-infected Mammalian Cells.  |  Buttrini, M. and De Conto, F. 2024. Front Biosci (Landmark Ed). 29: 116. PMID: 38538289
9. An engineered cellular carrier delivers miR-138-5p to enhance mitophagy and protect hypoxic-injured neurons via the DNMT3A/Rhebl1 axis.  |  Zhu, X., et al. 2024. Acta Biomater. 186: 424-438. PMID: 39122135

The preferred Rheb antibody is Rheb Antibody (B-12): sc-271509.