CD31/PECAM-1 Antibody (MEC7.46): sc-52714
- CD31/PECAM-1 Antibody (MEC7.46) is a rat monoclonal IgG1 provided at 100 µg/ml
- raised against polyoma middle T transformed EC line of mouse origin
- recommended for detection of mouse PECAM-1 expressed on the surface of endothelial cells of mouse origin by IP, IF and FCM
- available conjugated to FITC for IF, IHC(P) and FCM
- See CD31/PECAM-1 (H-3): sc-376764 for CD31/PECAM-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD31/PECAM-1 Antibody (MEC7.46). This work is in progress.
QUICK LINKS
PECAM-1 Antibody (MEC7.46) is a rat monoclonal IgG1 antibody that detects PECAM-1 in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). PECAM-1, also known as CD31, is a crucial glycoprotein that plays a significant role in the regulation of leukocyte migration and angiogenesis, making it essential for maintaining vascular integrity and facilitating immune responses. This glycoprotein is predominantly located at the intercellular junctions of endothelial cells, where PECAM-1 mediates cell-cell adhesion and communication, thereby influencing the permeability of blood vessels and the transmigration of immune cells during inflammatory responses. The proper functioning of PECAM-1 is vital for normal physiological processes, as dysregulation can lead to various pathological conditions, including chronic inflammation and tumor metastasis. Anti-PECAM-1 antibody (MEC7.46) is an invaluable tool for researchers studying vascular biology, immune responses, and related diseases, providing insights into the complex interactions that govern cell adhesion and migration.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD31/PECAM-1 Antibody (MEC7.46) References:
- Lymphatic endothelium expresses PECAM-1. | Sawa, Y., et al. 1998. Tissue Cell. 30: 377-82. PMID: 10091339
- Modulation of PECAM-1 expression and alternative splicing during differentiation and activation of hematopoietic cells. | Wang, Y., et al. 2003. J Cell Biochem. 88: 1012-24. PMID: 12616538
- The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis. | Goel, R., et al. 2007. Am J Physiol Gastrointest Liver Physiol. 293: G1205-14. PMID: 17932230
- ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. | Burim, RV., et al. 2009. Clin Exp Med. 9: 157-63. PMID: 19306055
- Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression. | DeLisser, H., et al. 2010. Proc Natl Acad Sci U S A. 107: 18616-21. PMID: 20926749
- Cerebral arterioles preparation and PECAM-1 expression in C57BL/6J and ApoE-/- mice. | Bengrine, A., et al. 2011. Front Biosci (Landmark Ed). 16: 2367-71. PMID: 21622182
- Effects of erythropoietin on ICAM-1 and PECAM-1 expressions on human umbilical vein endothelial cells subjected to oxidative stress. | Kamianowska, M., et al. 2011. Cell Biochem Funct. 29: 437-41. PMID: 21638298
- Antithrombotic actions of statins involve PECAM-1 signaling. | Moraes, LA., et al. 2013. Blood. 122: 3188-96. PMID: 24030383
- Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery. | Dan, M., et al. 2013. PLoS One. 8: e81051. PMID: 24278373
- Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1). | Umezawa, Y., et al. 2017. J Biol Chem. 292: 19639-19655. PMID: 28974577
- Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis. | Reckelkamm, SL., et al. 2023. Clin Oral Investig. 28: 59. PMID: 38157091
- Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy. | Wang, J., et al. 2024. PLoS One. 19: e0303010. PMID: 38748682
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD31/PECAM-1 Antibody (MEC7.46) | sc-52714 | 100 µg/ml | $322.00 | |||
CD31/PECAM-1 Antibody (MEC7.46) FITC | sc-52714 FITC | 100 tests in 2 ml | $336.00 |