IκB-ε Antibody (E-9): sc-374188
- IκB-ε Antibody (E-9) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-365 of IκB-ε of mouse origin
- recommended for detection of IκB-ε of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IκB-ε Antibody (E-9) for WB applications. These reagents are now offered in bundles with IκB-ε Antibody (E-9) (see ordering information below).
QUICK LINKS
IκB-ε Antibody (E-9) is a mouse monoclonal IgG2b antibody that detects IκB-ε in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IκB-ε plays a crucial role in the regulation of the NF-kB signaling pathway, which is essential for controlling immune responses, cell proliferation, and survival. IκB-ε is primarily located in the cytoplasm, where IκB-ε binds to NF-kB dimers, preventing their translocation to the nucleus and thereby inhibiting the expression of target genes involved in inflammation and immune responses. Proper functioning of IκB-ε is vital, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. Additionally, IκB-ε undergoes post-translational modifications, such as phosphorylation, which can influence stability and interaction with NF-kB, further emphasizing importance in cellular signaling. Anti-IκB-ε antibody (E-9) is an invaluable tool for researchers studying the intricate mechanisms of NF-kB regulation and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IκB-ε Antibody (E-9) References:
- Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells. | Bourke, E., et al. 2000. J Biol Chem. 275: 39996-40002. PMID: 10998424
- IkappaB family members function by different mechanisms. | Tam, WF. and Sen, R. 2001. J Biol Chem. 276: 7701-4. PMID: 11152669
- IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. | Goudeau, B., et al. 2003. Proc Natl Acad Sci U S A. 100: 15800-5. PMID: 14665694
- Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB. | Grosjean, J., et al. 2006. Biochem Biophys Res Commun. 340: 984-94. PMID: 16410078
- IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. | Alves, BN., et al. 2014. J Immunol. 192: 3121-32. PMID: 24591377
- p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation. | Tao, Z., et al. 2014. Proc Natl Acad Sci U S A. 111: 15946-51. PMID: 25349408
- Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia. | Mansouri, L., et al. 2015. J Exp Med. 212: 833-43. PMID: 25987724
- Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-κB axis. | Guan, F., et al. 2017. Oncotarget. 8: 105262-105275. PMID: 29285249
- Exclusivity and Compensation in NFκB Dimer Distributions and IκB Inhibition. | Ramsey, KM., et al. 2019. Biochemistry. 58: 2555-2563. PMID: 31033276
- Cloning and functional characterization of mouse IkappaBepsilon. | Simeonidis, S., et al. 1997. Proc Natl Acad Sci U S A. 94: 14372-7. PMID: 9405619
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IκB-ε Antibody (E-9) | sc-374188 | 200 µg/ml | $322.00 | |||
IκB-ε Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-535410 | 200 µg Ab; 40 µg BP | $361.00 | |||
IκB-ε Antibody (E-9): m-IgG2b BP-HRP Bundle | sc-549410 | 200 µg Ab; 10 µg BP | $361.00 |