HEXIM1 Antibody (E-7): sc-365413

HEXIM1 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects HEXIM1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HEXIM1 plays a crucial role in regulating gene expression by inhibiting the positive transcription elongation factor b (P-TEFb), a complex essential for the elongation phase of transcription in eukaryotic cells. The interaction of HEXIM1 with the 7SK small nuclear ribonucleic acid particle is vital for maintaining the stability of the P-TEFb complex, thereby influencing the transcriptional regulation of various genes. Notably, HEXIM1 and HEXIM2 can form stable homo- and hetero-oligomers through their C-terminal domains, which may enhance the formation of the 7SK ribonucleoprotein complex. The distinct expression patterns of HEXIM1 across different cell lines and human tissues suggest involvement in diverse biological processes and disease states, making anti-HEXIM1 antibody (E-7) an invaluable tool for researchers investigating transcriptional regulation and its implications in health and disease.

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HEXIM1 Antibody (E-7) References:

1. Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation.  |  Turano, M., et al. 2006. J Cell Physiol. 206: 603-10. PMID: 16222702
2. HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.  |  Li, Q., et al. 2007. Nucleic Acids Res. 35: 2503-12. PMID: 17395637
3. Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription.  |  Gurumurthy, M., et al. 2008. J Mol Biol. 378: 302-17. PMID: 18371977
4. HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb.  |  Ogba, N., et al. 2008. Cancer Res. 68: 7015-24. PMID: 18757415
5. Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis.  |  Ketchart, W., et al. 2013. Oncogene. 32: 3829-39. PMID: 22964639
6. Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy.  |  Neo, SH., et al. 2016. Oncotarget. 7: 5483-94. PMID: 26734838
7. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.  |  Tan, JL., et al. 2016. Mol Cell. 62: 34-46. PMID: 27058786
8. HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen.  |  Lama, R., et al. 2017. J Steroid Biochem Mol Biol. 168: 91-101. PMID: 28213333
9. HEXIM1 Peptide Exhibits Antimicrobial Activity Against Antibiotic Resistant Bacteria Through Guidance of Cell Penetrating Peptide.  |  Ho, PL., et al. 2019. Front Microbiol. 10: 203. PMID: 30800117
10. CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors.  |  Lloyd, SM., et al. 2022. Nat Commun. 13: 4408. PMID: 35906225

The preferred HEXIM1 antibody is HEXIM1 Antibody (D-8): sc-390059.