EY-cadherin Antibody (YB.2): sc-81791
- EY-cadherin Antibody (YB.2) is a mouse monoclonal IgG2a κ EY-cadherin antibody provided at 100 µg/ml
- raised against recombinant EY-cadherin of human origin
- recommended for detection of EY-cadherin of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EY-cadherin Antibody (YB.2). This work is in progress.
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EY-cadherin Antibody (YB.2) is a mouse monoclonal IgG2a kappa light chain antibody that detects EY-cadherin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-EY-cadherin antibody (YB.2) is available as a non-conjugated format. EY-cadherin, also known as CDH18, CDH14, or CDH24, is a 790 amino acid single-pass type I membrane protein characterized by five cadherin domains. EY-cadherin is predominantly expressed in the central nervous system (CNS), where EY-cadherin plays a crucial role in mediating cell-cell adhesion, essential for maintaining structural integrity and proper morphogenesis of neural tissues. EY-cadherin is involved in critical processes such as axon guidance and synaptic adhesion, facilitating communication between neurons. EY-cadherin′s structure, particularly its highly conserved C-terminal domain, is vital for adhesive properties, although EY-cadherin notably lacks the HAV cell adhesion sequence typical of type I cadherins. The gene encoding EY-cadherin is located on chromosome five, a region frequently deleted in various carcinomas, suggesting EY-cadherin may function as a tumor suppressor, further underscoring its importance in both normal cellular function and disease contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EY-cadherin Antibody (YB.2) References:
- Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. | Chalmers, IJ., et al. 1999. Genomics. 57: 160-3. PMID: 10191097
- Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin. | Shimoyama, Y., et al. 1999. J Biol Chem. 274: 11987-94. PMID: 10207020
- The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14. | Kools, P., et al. 1999. FEBS Lett. 452: 328-34. PMID: 10386616
- Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. | Shimoyama, Y., et al. 2000. Biochem J. 349: 159-67. PMID: 10861224
- Expression analysis of SIX3 and SIX6 in human tissues reveals differences in expression and a novel correlation between the expression of SIX3 and the genes encoding isocitrate dehyhrogenase and cadherin 18. | Aijaz, S., et al. 2005. Genomics. 86: 86-99. PMID: 15953543
- Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts). | Heikinheimo, K., et al. 2007. J Dent Res. 86: 544-9. PMID: 17525355
- Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. | Shibata, T., et al. 1997. J Biol Chem. 272: 5236-40. PMID: 9030594
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EY-cadherin Antibody (YB.2) | sc-81791 | 100 µg/ml | $339.00 |