EY-cadherin Inhibitors
EY-cadherin inhibitors are a class of compounds that target and inhibit the function of EY-cadherin, a type of cadherin protein involved in cell adhesion and the maintenance of tissue architecture. Cadherins are calcium-dependent adhesion molecules that play a critical role in mediating cell-cell interactions, especially in epithelial tissues where they help form tight junctions between adjacent cells. EY-cadherin is essential for maintaining the structural integrity of tissues by facilitating homophilic binding, where cadherin molecules on the surface of one cell bind to identical cadherin molecules on neighboring cells. Inhibitors of EY-cadherin function by disrupting these interactions, leading to changes in cell adhesion properties.
The inhibition of EY-cadherin can significantly impact cellular behavior, particularly in processes related to cell motility, polarity, and organization within tissues. By interfering with cadherin-mediated adhesion, these inhibitors can weaken the junctions between cells, altering how cells communicate and maintain their physical connections. This can lead to modifications in tissue structure and cellular dynamics, as cadherins are critical for maintaining the balance between cellular cohesion and movement. EY-cadherin inhibitors provide valuable tools for studying the molecular mechanisms of cell adhesion and the role of cadherins in tissue organization and remodeling. Through inhibition of EY-cadherin, researchers can explore how changes in cell-cell adhesion contribute to various cellular processes, including tissue development, wound healing, and the maintenance of epithelial barriers.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a natural alkaloid found in certain plants and has been studied for its potential to inhibit E-cadherin expression and function in cancer cells. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium pamoate has shown potential as an E-cadherin inhibitor in cancer therapy by interfering with its expression and downstream signaling pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK) and has been shown to increase E-cadherin expression in certain cancer cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane has been studied for its ability to inhibit E-cadherin expression and promote cancer cell apoptosis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCE-cadherin, also known as epithelial cadherin or CDH1, is a transmembrane glycoprotein that plays a pivotal role in the maintenance of cell-cell adhesion in epithelial tissues. This cell adhesion molecule is crucial for the formation and stabilization of adherens junctions, which are specialized structures at the cell membrane that mediate strong intercellular adhesion and maintain tissue integrity. E-cadherin inhibitors are a group of chemical compounds or biologics that can modulate the expression, function, or stability of E-cadherin in cells. These inhibitors target various steps of E-cadherin regulation and downstream signaling pathways, leading to altered cell-cell adhesion dynamics. Some E-cadherin inhibitors act by directly interacting with the extracellular domain of E-cadherin, interfering with its homophilic binding and weakening cell-cell interactions. Additionally, several intracellular signaling pathways regulate E-cadherin expression, such as the Wnt/β-catenin pathway, Rho GTPases, and transcription factors like Snail and Twist. E-cadherin inhibitors may target these pathways to affect the transcription, translation, or stability of E-cadherin protein, ultimately influencing cellular adhesion and motility. The search for E-cadherin inhibitors is of great interest in the scientific community due to the vital role of E-cadherin in epithelial homeostasis and its involvement in various diseases, particularly cancer. Dysregulation of E-cadherin is frequently observed in cancer metastasis, where loss or downregulation of E-cadherin leads to enhanced cellular motility and invasion, allowing tumor cells to disseminate to distant tissues. G is a polyphenol present in green tea, and studies have suggested its potential as an E-cadherin inhibitor in cancer therapy. | ||||||