Endothelin-1/EDN1/ET-1 Antibody (C7): sc-517436

ET-1 Antibody (C7) is a mouse monoclonal IgG2b kappa light chain antibody that detects ET-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ET-1 antibody (C7) is available as the non-conjugated format. The human endothelin family includes three isoforms: endothelin-1, endothelin-2, and endothelin-3, with endothelin-1 being a critical 21-amino acid peptide produced by vascular endothelial cells. This peptide plays a vital role in regulating vascular tone and blood pressure, as endothelin-1 is a potent vasoconstrictor that can significantly influence cardiovascular health. The importance of endothelin-1 extends beyond vasoconstriction; endothelin-1 also impacts various physiological processes, including cell proliferation and inflammation, making endothelin-1 a key player in both normal physiology and pathological conditions such as hypertension and heart failure. The activity of endothelin-1 is mediated through interaction with two receptor subtypes, ETA and ETB, which exhibit different affinities for the endothelin isoforms, thereby contributing to the complexity of biological effects. Understanding the function of endothelin-1 and signaling pathways is crucial for developing therapeutic strategies targeting cardiovascular diseases.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Endothelin-1/EDN1/ET-1 Antibody (C7) References:

1. The role of endothelins and their receptors in heart failure.  |  Giannessi, D., et al. 2001. Pharmacol Res. 43: 111-26. PMID: 11243712
2. Role of endothelin-1 in the migration of human olfactory gonadotropin-releasing hormone-secreting neuroblasts.  |  Romanelli, RG., et al. 2005. Endocrinology. 146: 4321-30. PMID: 15994351
3. Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3.  |  Arinami, T., et al. 1991. Am J Hum Genet. 48: 990-6. PMID: 2018043
4. The discovery, the present state, and the future prospects of endothelin.  |  Masaki, T. 1989. J Cardiovasc Pharmacol. 13 Suppl 5: S1-4; discussion S18. PMID: 2473280
5. Positive inotropic and vasoconstrictive effects of endothelin-1 in in vivo and in vitro experiments: characteristics and the role of L-type calcium channels.  |  Watanabe, T., et al. 1989. J Cardiovasc Pharmacol. 13 Suppl 5: S108-11 discussion s123. PMID: 2473282
6. Effect of endothelin-1 on calcium channel gating by agonists in vascular smooth muscle.  |  Godfraind, T., et al. 1989. J Cardiovasc Pharmacol. 13 Suppl 5: S112-7; discussion S123. PMID: 2473283
7. The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.  |  Inoue, A., et al. 1989. J Biol Chem. 264: 14954-9. PMID: 2670930
8. Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.  |  Itoh, Y., et al. 1988. FEBS Lett. 231: 440-4. PMID: 3282927
9. Research progress on the role of ET-1 in diabetic kidney disease.  |  Zhang, S., et al. 2023. J Cell Physiol. 238: 1183-1192. PMID: 37063089
10. Relationship Between Serum ET-1, HDL-C, and sVCAM-1 and Hearing Loss in Patients with Sudden Deafness.  |  Wang, ZH. and Zhang, HL. 2024. Appl Biochem Biotechnol. 196: 1376-1385. PMID: 37395946
11. Melatonin Inhibits ET-1 Production to Break Crosstalk Between Prostate Cancer and Bone Cells: Implication for Osteoblastic Bone Metastasis Treatment.  |  Lin, LW., et al. 2024. J Pineal Res. 76: e70000. PMID: 39415320
12. The role of endothelin in heart failure and hypertension.  |  Nguyen, BN. and Johnson, JA. 1998. Pharmacotherapy. 18: 706-19. PMID: 9692645

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Endothelin-1/EDN1/ET-1 Antibody (C7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Endothelin-1/EDN1/ET-1 Antibody (C7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Endothelin-1/EDN1/ET-1 Antibody (C7) Specifications

Alternate Product Name: EDN1

Product Clone Name: C7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 53-90

Epitope Target: ET-1

Epitope Species: human

Product Reactivity/Detection: ET-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Endothelin-1/EDN1/ET-1 Antibody (C7): N/A