m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Cryopyrin/NALP3/NLRP3 Antibody (6F12) for WB applications. These reagents are now offered in bundles with Cryopyrin/NALP3/NLRP3 Antibody (6F12) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cryopyrin Antibody (6F12) is a high quality monoclonal Cryopyrin antibody (also designated NLRP3 antibody, NLR family pyrin domain containing 3 antibody, or NALP3 antibody) suitable for the detection of the Cryopyrin protein of human origin. Cryopyrin Antibody (6F12) is available as the non-conjugated anti-Cryopyrin antibody. Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.