Aldose Reductase Antibody (G-1): sc-166919

Aldose Reductase Antibody (G-1) is a mouse monoclonal IgG2a antibody that detects Aldose Reductase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aldose Reductase plays a crucial role in cellular metabolism by catalyzing the reduction of various aldehydes, including the conversion of glucose to sorbitol, which is particularly significant in the context of diabetic complications. While this pathway is generally a minor contributor to glucose metabolism in most tissues, this process becomes critically important during diabetic hyperglycemia, as cells that take up glucose independently of insulin can accumulate excessive sorbitol, leading to hyperosmotic stress. This stress is a key factor in the development of diabetic complications such as neuropathy, retinopathy, and cataracts. Anti-Aldose Reductase antibody (G-1) provides reliable detection of this enzyme, facilitating research into its role in diabetes and related metabolic disorders. Aldose Reductase (G-1) antibody′s specificity and sensitivity make this tool invaluable for studying Aldose Reductase interactions and functions in various biological contexts, contributing to a deeper understanding of implications in health and disease.

The preferred Aldose Reductase antibody is Aldose Reductase Antibody (H-6): sc-166918.