Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (64): sc-65824

AChRα1 Antibody (64) is a rat monoclonal IgG2a antibody that detects AChRα1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunofluorescence (IF). AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission. This multi-pass membrane protein, consisting of 482 amino acids, is essential for the proper functioning of the neuromuscular junction, where AChRα1 facilitates the binding of acetylcholine and the subsequent influx of ions that trigger muscle contraction. Notably, AChRα1 exists in two alternatively spliced isoforms; isoform 1 is specifically expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. The diverse expression of these isoforms underscores AChRα1′s importance in both muscle function and central nervous system signaling. Furthermore, AChRα1 activity is tightly regulated by acetylcholinesterase, which rapidly hydrolyzes acetylcholine to terminate synaptic transmission, highlighting AChRα1′s critical role in maintaining neurotransmitter balance and preventing overstimulation. Anti-AChRα1 antibody (64) serves as an invaluable tool for researchers studying neuromuscular and neurological functions.

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Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (64) References:

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The preferred Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody is Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (153): sc-65829.