Date published: 2025-9-9

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acetylated alpha Tubulin 항체 (6-11B-1): sc-23950

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데이터 시트
  • acetylated alpha Tubulin 항체 6-11B-1 는 마우스 monoclonal IgG2b κ acetylated alpha Tubulin 항체, 348간행물에 인용, 이며 200 µg/ml으로 제공합니다.
  • C. abortus의 S26/3 양 분리주에 대해 항원화
  • acetylated alpha Tubulin 항체 (6-11B-1)는 WB, IP, IF and IHC(P)으로 mammalian species, zebrafish, Drosophila and Xenopus유래의 acetylated α Tubulin 를 감지하는 데에 추천한다.; non-acetylated α Tubulin or other lysine acetylation sites와 교차반응이 없습니다.
  • 항-acetylated alpha Tubulin 항체(6-11B-1)는 IP용 agarose와 결합되어 이용 가능하며, WB, IHC(P), ELISA용 HRP와 결합되어 이용 가능하며, IF, IHC(P), FCM용 phycoerythrin 또는 FITC와 결합되어 이용 가능합니다.
  • WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
  • WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
  • acetylated alpha Tubulin (6-11B-1): sc-23950무료10 µg 샘플을 신청하려면 기술지원팀 (또는 로컬 디스트리뷰터)에 연락주세요.
  • m-IgG Fc BP-HRPm-IgG2b BP-HRP 는 acetylated alpha Tubulin 항체 (6-11B-1) 가 WB and IHC(P) 에 응용될 때 우선으로 사용하는 이차 항체 검사 시약입니다.이 시약은acetylated alpha Tubulin 항체(6-11B-1) 와 세트로 제공드립니다. (아래의 주문 정보를 참고해 주시길 바랍니다).

빠른 링크

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아세틸화된 α 튜불린 항체(6-11B-1)는 Strongylocentrotus purpuratus(성게) 정자 액소네의 외팔에 대해 생성된 마우스 단일 클론 IgG2b kappa 경쇄 항체로, 포유류 종, 제브라피쉬, 초파리, 그리고 켄토브루스의 알파 튜불린의 아세틸화된 형태를 구체적으로 인식합니다. 알파 튜불린은 베타 튜불린과 함께 이종 이량체를 형성하여 중합하여 미세소관을 생성하는데, 미세소관은 세포의 형태를 유지하고 세포 내 수송을 가능하게 하며 세포 분열을 촉진하는 세포 골격의 필수 구성 요소입니다. 리신 40번 위치의 α-튜불린의 아세틸화는 번역 후 변형으로 미세소관의 안정성을 강화하고 모터 단백질과의 상호작용에 영향을 미치기 때문에 세포 내 이동, 섬모와 편모의 움직임, 세포 신호 전달 경로와 같은 과정에 영향을 미칩니다. 아세틸화된 α-튜불린의 기능과 조절을 이해하는 것은 신경 퇴행성 질환, 암, 발달 생물학에 대한 통찰력을 얻는 데 중요합니다. 항-아세틸화 α-튜불린 항체(6-11B-1)는 웨스턴 블랏팅(WB), 면역침전법(IP), 면역형광법(IF), 파라핀 포매 섹션 면역조직화학법(IHCP)과 같은 응용 분야에 적합하며, 다양한 생물학적 시스템에서 미세소관 역학과 세포 골격 조직을 연구하는 연구자들에게 유용한 도구를 제공합니다.

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

Alexa Fluor®는 미국 오리건주 Molecular Probes Inc.의 상표입니다.

LI-COR®와 Odyssey®는 LI-COR Biosciences의 등록 상표입니다.

acetylated alpha Tubulin 항체 (6-11B-1) 참고문헌:

  1. 아세틸화된 튜불린의 정량화.  |  Chesta, ME., et al. 2013. Cytoskeleton (Hoboken). 70: 297-303. PMID: 23596183
  2. 아세틸화된 α-튜불린은 정자 운동성이 좋지 않은 개인에서 감소합니다.  |  Bhagwat, S., et al. 2014. Fertil Steril. 101: 95-104.e3. PMID: 24268707
  3. 튜불린 아세틸화: 담당 효소, 생물학적 기능 및 인간 질병.  |  Li, L. and Yang, XJ. 2015. Cell Mol Life Sci. 72: 4237-55. PMID: 26227334
  4. 아세틸화된 튜불린은 생쥐의 촉각에 필수적입니다.  |  Morley, SJ., et al. 2016. Elife. 5: PMID: 27976998
  5. 마우스 수정 및 초기 발달 중 미세소관의 아세틸화된 알파-튜뷸린.  |  Schatten, G., et al. 1988. Dev Biol. 130: 74-86. PMID: 3053299
  6. 아세틸화된 α-튜뷸린 K394는 미세소관의 안정성을 조절하여 축삭 말단의 성장을 형성합니다.  |  Saunders, HAJ., et al. 2022. Curr Biol. 32: 614-630.e5. PMID: 35081332
  7. 아세틸화된 α-튜불린은 생쥐의 허혈성 뇌졸중 후 수지상 돌기의 손상을 완화합니다.  |  Yang, C., et al. 2023. CNS Neurosci Ther. 29: 2327-2338. PMID: 36965035
  8. SPAST 유전성 경련성 하반신 마비 환자 PBMC에서 아세틸화된 α-튜불린 감소.  |  Wali, G., et al. 2023. Front Neurosci. 17: 1073516. PMID: 37144097
  9. 센트로좀 증폭은 튜불린 아세틸화를 미세 조정하여 세포 내 조직을 차등적으로 제어합니다.  |  Monteiro, P., et al. 2023. EMBO J. 42: e112812. PMID: 37403793
  10. 아세틸화된 α-튜불린 및 α-시누클레인: α-시누클레인 올리고머화에 대한 생리적 상호 작용 및 기여.  |  Calogero, AM., et al. 2023. Int J Mol Sci. 24: PMID: 37569662

주문정보

제품명카탈로그 번호 단위가격수량관심품목

acetylated alpha Tubulin 항체 (6-11B-1)

sc-23950
200 µg/ml
$316.00

acetylated alpha Tubulin (6-11B-1): m-IgG Fc BP-HRP 번들

sc-525509
200 µg Ab; 10 µg BP
$354.00

acetylated alpha Tubulin (6-11B-1): m-IgG2b BP-HRP 번들

sc-549568
200 µg Ab; 10 µg BP
$354.00

acetylated alpha Tubulin 항체 (6-11B-1) AC

sc-23950 AC
500 µg/ml, 25% agarose
$416.00

acetylated alpha Tubulin 항체 (6-11B-1) HRP

sc-23950 HRP
200 µg/ml
$316.00

acetylated alpha Tubulin 항체 (6-11B-1) FITC

sc-23950 FITC
200 µg/ml
$330.00

acetylated alpha Tubulin 항체 (6-11B-1) PE

sc-23950 PE
200 µg/ml
$343.00

acetylated alpha Tubulin 항체 (6-11B-1) Alexa Fluor® 488

sc-23950 AF488
200 µg/ml
$357.00

acetylated alpha Tubulin 항체 (6-11B-1) Alexa Fluor® 546

sc-23950 AF546
200 µg/ml
$357.00

acetylated alpha Tubulin 항체 (6-11B-1) Alexa Fluor® 594

sc-23950 AF594
200 µg/ml
$357.00

acetylated alpha Tubulin 항체 (6-11B-1) Alexa Fluor® 647

sc-23950 AF647
200 µg/ml
$357.00

acetylated alpha Tubulin 항체 (6-11B-1) Alexa Fluor® 680

sc-23950 AF680
200 µg/ml
$357.00

acetylated alpha Tubulin 항체 (6-11B-1) Alexa Fluor® 790

sc-23950 AF790
200 µg/ml
$357.00

How do I get the correct catalog number of the Alexa Fluor 488 Labelled acetylated alpha tubulin ab (sc-23950)

Asked by: Sree
Thank you for your question. The part number for the AF488 is sc-23950 AF488. For a price quote and ship date please email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-03-27

For sc-23950, which is clone 6-11B-1 mouse monoclonal to acetylated alpha-tubulin, what PURIFICATION  METHOD was used?

Asked by: DavidFR
Thank you for your question. Santa Cruz Biotechnology antibodies are affinity purified.
Answered by: BlakeJ
Date published: 2025-03-07

1. What dilution works well for acetylated alpha Tubulin Antibody (6-11B-1) Alexa Fluor® 488 in PBMCs? 2. What isotype control is suitable for this conjugated antibody?

Asked by: Gautam
Thank you for contacting Santa Cruz Biotechnology . We would need to know what application the antibody is used for to better assist you. For help please contact scbt@scbt.com. Here are the controls we offer :https://www.scbt.com/browse/Control-IgGs-and-IgG-Conjugates/_/N-1j3ajah
Answered by: BlakeJ
Date published: 2024-05-14

We have lot # HQ422 of prodfuct sc-23950. I am getting a very week signal at 1:200 on fixed airway epithelial cells. Is this lot expired? Thanks. Shubha

Asked by: Shubha
Thank you for your question. We warranty our antibodies for 1 year from date of purchase . Lot HQ422 is not a valid lot number . Please give us a call or email us to discuss your results. scbt@scbt.com or (800)457-3801.
Answered by: BlakeJ
Date published: 2023-12-01

The product specifications list amino acids 149-448, however, in previous questions it was noted that this product recognizes Ac-K40. Can you please confirm which epitope this antibody recognizes?

Asked by: Laura
Thank you for your question. The epitope range is 149-448.
Answered by: BlakeJ
Date published: 2023-11-14

Hi, interested in buying an anti-acetyl-alpha Tubulin antibody to test the effect of HDAC8 inhibitors by WB. Wondering if I could purchase or get an small aliquot to test it before placing the order of a full product

Asked by: CarlosPR
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-04-07

We have purchased and used acetylated α Tubulin Antibody (6-11B-1): sc-23950 antibody. It is working quite well. However we need to know the which amino acid residue the antibody is reacting with? Kindly tell me particular epitope to which ab binds.

Asked by: Nitish
Thank you for your question. This mouse monoclonal antibody recognizes endogenous levels of α-tubulin protein only when acetylated at Lys40 (Lysine 40).
Answered by: Technical Support
Date published: 2024-11-07

Hi, I would like to know which light chain is in this antibody (e.g, kappa I, II or V). I would like to undertsand if I can purify the antibody with protein L resin. I would like to find out the affinity of the antibody with protein L. Thank you!

Asked by: Foram
Thank you for your question. Since acetylated α Tubulin Antibody (6-11B-1): sc-23950 is a mouse IgG2 antibody it can be purified using Protein A or Protein A/G. For further information please contact our technical service directly.
Answered by: Technical Support Europe
Date published: 2019-02-04
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Rated 5 out of 5 by from Immunofluorescence - murine airway organoidWorked well for IF-C, using murine epithelial airway organoids, fixed in 4% PFA, permeabilization solution: 0.5% Triton in PBS, blocking solution: 1x ROTI Block, Dilution: 1:200.
Date published: 2025-04-17
Rated 4 out of 5 by from acetylated alpha Tubulin Antibody (6-11B-1)Good signal at the expected molecular weight of acetylated tubulin.
Date published: 2024-11-05
Rated 5 out of 5 by from Excellent in WB!Clear signal was detected in WB of mouse brain homogenate!
Date published: 2024-08-26
Rated 5 out of 5 by from muy buen reconocimiento de la proteínaLo probé con una linea celular de mosquito y reconoció la proteína muy bien
Date published: 2023-10-03
Rated 5 out of 5 by from Acet. alpha-tubulinAcet. Alpha-tubulin AlexaFluor 488 antibody was used 1/100 diluted in D-PBS/Live-Dead stain (1:1000), supplemented with 60µg/ml human IgG (Sigma Aldrich) at 8◦C for 30 min. After that, cells were washed in FACS buffer (D-PBS/0.1% BSA), fixed in 4% PFA at room temperature (RT), and analyzed by flow cytometry.
Date published: 2023-01-16
Rated 5 out of 5 by from GREAT ANTIBODIES!Really good antibody. Whole cell lysate, Primary: 1:200, Secondary: 1:4000
Date published: 2022-06-14
Rated 5 out of 5 by from Good antibody for ac-tubulinGood antibody for ac-tubulin detection in WB.Very clean and strong signal.
Date published: 2020-11-17
Rated 5 out of 5 by from Primary cilia - ImmunofluorescenceThe antibody works quite well at 1/1000 in fixed cells and is highly specific.
Date published: 2019-07-29
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acetylated alpha Tubulin 항체 (6-11B-1) is rated 4.8 out of 5 by 46.
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