Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
UCP4 Antibody (A-5) is a high quality monoclonal UCP4 antibody (also designated SLC25A27 antibody) suitable for the detection of the UCP4 protein of mouse, rat and human origin. UCP4 Antibody (A-5) is available as the non-conjugated anti-UCP4 antibody. A significant portion of the metabolic rate of endotherm is attributable to counteracting uncoupling, wherein a flux of protons down the electrochemical gradient generates heat independently of ATP production. Uncoupling is apparent in thermogenic brown adipose tissue, which expresses tissue-specific uncoupling protein (UCP), suggesting that innate uncoupling and metabolic rate are regulated by UCPs. UCPs are a family of mitochondrial transporter proteins that are implicated in thermoregulatory heat production and maintenance of the basal metabolic rate. A brain-specific novel member of UCP family, UCP4, is most related to UCP3 and possesses features characteristic of mitochondrial transporter proteins. Unlike other known UCPs, UCP4 mRNAs are expressed in both fetal and adult brain tissues. Human UCP4, a 323 amino acid protein, has been speculated on its participation in apoptosis because of its early phylogenetic occurrence. Brain UCP4 mRNA rose by 1.5 fold in response to acute cold exposure, suggesting UCP4 is involved in tissue-specific thermoregulation and metabolic changes. The UCP-specific sequences are found in the first, second and fourth alpha-helices and are involved in fatty acid anion binding and translocation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.