Date published: 2026-6-4
Visit Santa Cruz Animal Health

1-800-457-3801

SCBT Portrait Logo
Seach Input
Contact Us
Sign In Account
Quick Order
Cart (0)
Tyrosinase Antibody (0.N.596) - Western Blotting - Image 379978
Tyrosinase Antibody (0.N.596): sc-73243. Western blot analysis of Tyrosinase expression in A-375 (A), c4 (B), ARPE-19 (C), Raji (D), Jurkat (E) and Hep G2 (F) whole cell lysates.
Tyrosinase Antibody (0.N.596) - Western Blotting - Image 379978
Tyrosinase Antibody (0.N.596): sc-73243. Western blot analysis of Tyrosinase expression in A-375 (A), c4 (B), ARPE-19 (C), Raji (D), Jurkat (E) and Hep G2 (F) whole cell lysates.
Tyrosinase Antibody (0.N.596) - Immunohistochemistry - Image 356395
Tyrosinase Antibody (0.N.596): sc-73243. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic staining of melanocytes.
Tyrosinase Antibody (0.N.596) - Western Blotting - Image 30125
Tyrosinase Antibody (0.N.596): sc-73243. Western blot analysis of Tyrosinase expression in non-transfected 293T: sc-117752 (A), truncated human Tyrosinase transfected 293T: sc-113710 (B) and A-375 (C) whole cell lysates.
Tyrosinase Antibody (0.N.596): sc-73243. Western blot analysis of Tyrosinase expression in A-375 (A), c4 (B), ARPE-19 (C), Raji (D), Jurkat (E) and Hep G2 (F) whole cell lysates.

Tyrosinase Antibody (0.N.596): sc-73243

4.0(1)
Write a reviewAsk a question

Datasheets
  • Tyrosinase Antibody (0.N.596) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
  • raised against recombinant Tyrosinase of human origin
  • recommended for detection of Tyrosinase of mouse, rat and human origin by WB, IP, IF and IHC(P)
  • See Tyrosinase (T311): sc-20035 for Tyrosinase antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Tyrosinase Antibody (0.N.596) for WB and IHC(P) applications. These reagents are now offered in bundles with Tyrosinase Antibody (0.N.596) (see ordering information below).
Gene Editing Promo Banner

QUICK LINKS

Support Products
Description
Gene Info
Datasheets and Protocols
Research Information

SEE ALSO...

Tyrosinase Antibody (0.N.596) is a mouse monoclonal IgG2a antibody that detects tyrosinase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Tyrosinase plays a crucial role in the production of melanin, the primary pigment responsible for coloration in vertebrates, by catalyzing the rate-limiting step of tyrosine hydroxylation during melanin biosynthesis. Anti-tyrosinase antibody (0.N.596) enables research into enzymatic activity vital for pigmentation, protection against UV radiation, and oxidative stress. Deficiencies in tyrosinase activity can lead to various forms of albinism, highlighting its importance in skin and eye health. Additionally, tyrosinase interacts with related proteins such as TRP1 and TRP2, which are also expressed in melanocytes and contribute to melanin synthesis. These proteins share structural similarities, including a transmembrane region and metal-binding sites, and are localized within the melanosomal membrane, forming a multi-enzyme complex that enhances the stability and functionality of tyrosinase. Tyrosinase monoclonal antibody (0.N.596) serves as an essential tool for researchers studying pigmentation disorders, melanin biosynthesis, and the molecular mechanisms underlying these processes.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Tyrosinase Antibody (0.N.596) References:

  1. Immunohistochemical expression of melan-A and tyrosinase in uveal melanoma.  |  Fernandes, BF., et al. 2007. J Carcinog. 6: 6. PMID: 17445277
  2. Phenylethylamide and phenylmethylamide derivatives as new tyrosinase inhibitors.  |  Le Mellay-Hamon, V. and Criton, M. 2009. Biol Pharm Bull. 32: 301-3. PMID: 19182394
  3. Synthesis of glabridin derivatives as tyrosinase inhibitors.  |  Jirawattanapong, W., et al. 2009. Arch Pharm Res. 32: 647-54. PMID: 19471877
  4. Suicide inactivation of tyrosinase in its action on tetrahydropterines.  |  Muñoz-Muñoz, JL., et al. 2011. J Enzyme Inhib Med Chem. 26: 728-33. PMID: 21299451
  5. Tyrosinase Electrochemical Biosensors Monitoring Medicinally Significant Substances.  |  Sýs, M. and Vytřas, K. 2018. Curr Med Chem. 25: 3988-4006. PMID: 28748761
  6. Tyrosinase-Loaded Multicompartment Microreactor toward Melanoma Depletion.  |  Godoy-Gallardo, M., et al. 2019. ACS Appl Mater Interfaces. 11: 5862-5876. PMID: 30605301
  7. Functionality study of chalcone-hydroxypyridinone hybrids as tyrosinase inhibitors and influence on anti-tyrosinase activity.  |  Singh, LR., et al. 2020. J Enzyme Inhib Med Chem. 35: 1562-1567. PMID: 32746652
  8. Antamanide Analogs as Potential Inhibitors of Tyrosinase.  |  Honisch, C., et al. 2022. Int J Mol Sci. 23: PMID: 35682928
  9. Biomedical applications of tyrosinases and tyrosinase inhibitors.  |  Pisano, L., et al. 2024. Enzymes. 56: 261-280. PMID: 39304289
  10. Tyrosinase inhibitors from Anacardium occidentale fruits.  |  Kubo, I., et al. 1994. J Nat Prod. 57: 545-51. PMID: 8021657

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tyrosinase Antibody (0.N.596)

sc-73243
200 µg/ml
$322.00

Tyrosinase Antibody (0.N.596): m-IgG Fc BP-HRP Bundle

sc-539464
200 µg Ab; 10 µg BP
$361.00

Tyrosinase Antibody (0.N.596): m-IgG2a BP-HRP Bundle

sc-546709
200 µg Ab; 10 µg BP
$361.00

Can Tyrosinase (0.N.596): sc-73243 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: cjMara
Thank you for your question. Yes, Tyrosinase (0.N.596): sc-73243 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-01
  • y_2026, m_6, d_4, h_10CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.46
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_73243, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 106ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Positive band observed in WB in human TyrosinasePositive band observed in WB in human Tyrosinase transfected 293T and A-375 whole cell lysates. -SCBT QC
Date published: 2014-12-08
  • y_2026, m_6, d_4, h_10
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.46
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_73243, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
Tyrosinase Antibody (0.N.596) is rated 4.0 out of 5 by 1.
  • y_2026, m_6, d_4, h_10
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.46
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_73243, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 106ms
  • REVIEWS, PRODUCT
1-800-457-3801
Visit Santa Cruz Animal Health|Visit San Juan Ranch
Santa Cruz Animal Health is a leading provider of animal health care products. ©2026 Santa Cruz Biotechnology Inc. All Rights Reserved.
Toll-Free: 1-800-457-3801 - Terms & Conditions | Privacy Policy | Legal
“Santa Cruz Animal Health”, “San Juan Ranch”, the San Juan Ranch logo, “UltraCruz”, “Supplement of Champions”, are registered trademarks of Santa Cruz Biotechnology, Inc. All other trademarks are the property of their respective owners.