TRPM6 Antibody (D-6): sc-365536
- TRPM6 Antibody (D-6) is a mouse monoclonal IgG1 κ TRPM6 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1225-1524 mapping within an internal region of TRPM6 of human origin
- TRPM6 Antibody (D-6) is recommended for detection of TRPM6 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TRPM6 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for TRPM6 Antibody (D-6) for WB and IHC(P) applications. This reagent is now offered in a bundle with TRPM6 Antibody (D-6) (see ordering information below).
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TRPM6 Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRPM6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-TRPM6 antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRPM6, also known as transient receptor potential cation channel, subfamily M, member 6, plays a vital role in magnesium homeostasis, which is essential for numerous cellular processes, including enzyme function, DNA synthesis, and cellular signaling. Located primarily in the kidney and colon, TRPM6 is a multi-pass membrane protein that facilitates the active transport of magnesium ions across epithelial cells, thereby influencing magnesium absorption in the gut and kidney. This function is particularly important as magnesium deficiency can lead to various health issues, including cardiovascular diseases, osteoporosis, and metabolic disorders. By understanding TRPM6′s role in magnesium transport, researchers can explore potential therapeutic targets for conditions associated with magnesium imbalance.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRPM6 Antibody (D-6) References:
- Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. | Walder, RY., et al. 2002. Nat Genet. 31: 171-4. PMID: 12032570
- Long-term follow-up of a patient with primary hypomagnesaemia and secondary hypocalcaemia due to a novel TRPM6 mutation. | Esteban-Oliva, D., et al. 2009. Eur J Pediatr. 168: 439-42. PMID: 18548273
- Insight into the molecular regulation of the epithelial magnesium channel TRPM6. | Cao, G., et al. 2008. Curr Opin Nephrol Hypertens. 17: 373-8. PMID: 18660673
- A case of hypomagnesemia with secondary hypocalcemia caused by Trpm6 gene mutation. | Apa, H., et al. 2008. Indian J Pediatr. 75: 632-4. PMID: 18759094
- EGF increases TRPM6 activity and surface expression. | Thebault, S., et al. 2009. J Am Soc Nephrol. 20: 78-85. PMID: 19073827
- Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. | Song, Y., et al. 2009. BMC Med Genet. 10: 4. PMID: 19149903
- Dietary inulin in mice stimulates Mg2+ absorption and modulates TRPM6 and TRPM7 expression in large intestine and kidney. | Rondón, LJ., et al. 2008. Magnes Res. 21: 224-31. PMID: 19271420
- Regulation of the epithelial Mg2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA). | Cao, G., et al. 2009. J Biol Chem. 284: 14788-95. PMID: 19329436
- [Molecular physiological study of electrolyte transporters in renal tubular epithelial cells]. | Ikari, A. 2009. Yakugaku Zasshi. 129: 1025-31. PMID: 19721377
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRPM6 Antibody (D-6) | sc-365536 | 200 µg/ml | $322.00 | |||
TRPM6 Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-552840 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRPM6 Antibody (D-6) AC | sc-365536 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TRPM6 Antibody (D-6) HRP | sc-365536 HRP | 200 µg/ml | $322.00 | |||
TRPM6 Antibody (D-6) FITC | sc-365536 FITC | 200 µg/ml | $336.00 | |||
TRPM6 Antibody (D-6) PE | sc-365536 PE | 200 µg/ml | $349.00 | |||
TRPM6 Antibody (D-6) Alexa Fluor® 488 | sc-365536 AF488 | 200 µg/ml | $364.00 | |||
TRPM6 Antibody (D-6) Alexa Fluor® 546 | sc-365536 AF546 | 200 µg/ml | $364.00 | |||
TRPM6 Antibody (D-6) Alexa Fluor® 594 | sc-365536 AF594 | 200 µg/ml | $364.00 | |||
TRPM6 Antibody (D-6) Alexa Fluor® 647 | sc-365536 AF647 | 200 µg/ml | $364.00 | |||
TRPM6 Antibody (D-6) Alexa Fluor® 680 | sc-365536 AF680 | 200 µg/ml | $364.00 | |||
TRPM6 Antibody (D-6) Alexa Fluor® 790 | sc-365536 AF790 | 200 µg/ml | $364.00 |