TRAF2 Antibody (D-12): sc-365287
- TRAF2 Antibody (D-12) is a mouse monoclonal IgG3 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of TRAF2 of human origin
- recommended for detection of TRAF2 of mouse, rat and human origin by WB, IP, IF and ELISA
- See TRAF2 (F-2): sc-136999 for TRAF2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for TRAF2 Antibody (D-12) for WB applications. This reagent is now offered in a bundle with TRAF2 Antibody (D-12) (see ordering information below).
TRAF2 Antibody (D-12) is a mouse monoclonal IgG3 antibody that detects TRAF2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRAF2 plays a crucial role in mediating tumor necrosis factor (TNF) receptor signaling, particularly through interaction with TNF receptor 1 (TNF-R1) and TNF-R2, which are integral to the TNF receptor superfamily. TRAF2 is primarily located in the cytoplasm, where TRAF2 forms heterodimeric complexes with TRAF1 and other signaling molecules, facilitating the transmission of signals that regulate various cellular processes, including inflammation and apoptosis. Proper functioning of TRAF2 is vital for maintaining immune responses and cellular homeostasis, as dysregulation of this signaling pathway can lead to pathological conditions such as autoimmune diseases and cancer. anti-TRAF2 antibody (D-12) is an essential tool for researchers aiming to explore the complexities of TNF receptor-mediated signaling and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRAF2 Antibody (D-12) References:
- TRAF2 is essential for TNF-alpha-induced osteoclastogenesis. | Kanazawa, K. and Kudo, A. 2005. J Bone Miner Res. 20: 840-7. PMID: 15824857
- TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. | Yang, CY., et al. 2016. Cell Signal. 28: 145-51. PMID: 26521044
- TRAF2 in osteotropic breast cancer cells enhances skeletal tumour growth and promotes osteolysis. | Peramuhendige, P., et al. 2018. Sci Rep. 8: 39. PMID: 29311633
- RACK1/TRAF2 regulation of modulator of apoptosis-1 (MOAP-1). | Law, J., et al. 2018. Biochim Biophys Acta Mol Cell Res. 1865: 684-694. PMID: 29470995
- Comparison of Target Recognition by TRAF1 and TRAF2. | Kim, CM. and Park, HH. 2020. Int J Mol Sci. 21: PMID: 32326186
- TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy. | Zhu, H., et al. 2020. Biomed Res Int. 2020: 1641340. PMID: 32566659
- TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells. | Xie, X., et al. 2021. Cell Mol Immunol. 18: 2262-2274. PMID: 33203937
- A cell-penetrating CD40-TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion. | Portillo, JC., et al. 2021. FASEB J. 35: e21412. PMID: 33675257
- Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells. | Palumbo, C., et al. 2022. Int J Biochem Cell Biol. 145: 106193. PMID: 35257890
- Peptidomimetics for CVD screened via TRADD-TRAF2 complex interface assessments. | Manikandan, A., et al. 2023. In Silico Pharmacol. 11: 28. PMID: 37899969
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRAF2 Antibody (D-12) | sc-365287 | 200 µg/ml | $322.00 | |||
TRAF2 Antibody (D-12): m-IgG3 BP-HRP Bundle | sc-550423 | 200 µg Ab; 40 µg BP | $361.00 | |||
TRAF2 (D-12) Neutralizing Peptide | sc-365287 P | 100 µg/0.5 ml | $69.00 |