Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II (Pol II) and several basal transcription factors to form the preinitiation complex (PIC). After initiation, promotor-specific contacts between the PIC and Pol II are disrupted, thus allowing elongation (a process regulated by Pol II and several proteins called elongation factors) to begin. TCEA1(Transcription elongation factor A protein 1), also known as TFIIS or SII, is an elongation factor that is essential for proper elongation past DNA arresting sites. When template-encoded arresting sites trap elongating RNA polymerases, the transcription complex becomes locked, preventing efficient elongation. TCEA1 binds to Pol II and functions to cleave the nascent transcript, thereby unlocking the complex and allowing transcription to continue. Localized to the nucleus, TCEA1 contains three independently-folding domains, all of which are necessary for proper binding to Pol II. Defects in the gene encoding TCEA1 are implicated in salivary gland pleiomorphic adenomas, which are the most common form of benign epithelial tumors of the salivary gland.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.