SUMF1 Antibody (A-4): sc-374102

SUMF1 Antibody (A-4) is a mouse monoclonal IgG2b antibody that detects SUMF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SUMF1, also known as sulfatase modifying factor 1 or FGE, is a crucial 374 amino acid protein that resides in the lumen of the endoplasmic reticulum and is essential for the proper functioning of sulfatases, which are enzymes responsible for removing sulfate residues from various substrates. The unique aspect of SUMF1′s function lies in SUMF1′s ability to post-translationally modify sulfatase cysteine residues into Cα-formylglycine, a necessary component for sulfatase activity. This modification directly influences the enzymatic activity of sulfatases, which play significant roles in various biological processes, including the metabolism of glycosaminoglycans and the degradation of sulfated compounds. Deficiencies in SUMF1 can lead to multiple sulfatase deficiency, a serious disorder that manifests in a range of neurological and developmental issues, underscoring SUMF1′s importance in maintaining cellular health and function. SUMF1 (A-4) antibody serves as an invaluable tool for researchers studying sulfatase activity and related disorders, providing insights into the molecular mechanisms underlying these critical biological processes.

The preferred SUMF1 antibody is SUMF1 Antibody (B-9): sc-376035.