Rtn-1/2 Antibody (4A69): sc-71981
- Rtn-1/2 Antibody (4A69) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against the small cell lung cancer cell line NCI-H82
- recommended for detection of Rtn-1 and Rtn-2 of human, rabbit and Rhesus monkey origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rtn-1/2 Antibody (4A69) for WB applications. These reagents are now offered in bundles with Rtn-1/2 Antibody (4A69) (see ordering information below).
Rtn-1/2 Antibody (4A69) is a mouse monoclonal IgG1 antibody that detects Rtn-1 in human, rabbit, and Rhesus monkey samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Rtn-1, also known as neuroendocrine-specific protein, plays a crucial role in the endoplasmic reticulum, where Rtn-1 is involved in neuroendocrine secretion and membrane trafficking. Rtn-1 is essential for maintaining cellular homeostasis and facilitating the proper functioning of neuroendocrine cells, which are vital for hormone release and signaling. The Rtn-1 gene, located on human chromosome 14q23.1, produces three isoforms—Rtn-1A, Rtn-1B, and Rtn-1C—through alternative splicing, allowing for diverse functional roles in various tissues. The presence of Rtn-1 in neural and neuroendocrine tissues underscores Rtn-1′s importance in the nervous system and potential implications in neurodegenerative diseases. Anti-Rtn-1/2 antibody (4A69) serves as an invaluable tool for researchers exploring the intricate functions of Rtn-1 and its involvement in cellular processes.
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Rtn-1/2 Antibody (4A69) References:
- NSP2 forms viroplasms during Dendrolimus punctatus cypovirus infection. | Xu, C., et al. 2019. Virology. 533: 68-76. PMID: 31125854
- SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation. | Xu, Z., et al. 2022. Proc Natl Acad Sci U S A. 119: e2204539119. PMID: 35878012
- SAV Nsp2 regulates NF-κB signaling to induce inflammatory responses by targeting host DDX3. | Gao, S., et al. 2023. Dev Comp Immunol. 140: 104612. PMID: 36473548
- Flexibility of the Rotavirus NSP2 C-Terminal Region Supports Factory Formation via Liquid-Liquid Phase Separation. | Nichols, SL., et al. 2023. J Virol. 97: e0003923. PMID: 36749077
- SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κB. | Lacasse, É., et al. 2023. Viruses. 15: PMID: 36851549
- The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression. | Naeli, P., et al. 2023. J Cell Sci. 136: PMID: 37732428
- Low phosphorus promotes NSP1-NSP2 heterodimerization to enhance strigolactone biosynthesis and regulate shoot and root architecture in rice. | Kun Yuan,., et al. 2023. Mol Plant. 16: 1811-1831. PMID: 37794682
- GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis. | Mou, C., et al. 2023. Cell Commun Signal. 21: 361. PMID: 38110975
- Research Progress of Porcine Reproductive and Respiratory Syndrome Virus NSP2 Protein. | Liu, B., et al. 2023. Viruses. 15: PMID: 38140551
- Rotavirus NSP2: A Master Orchestrator of Early Viral Particle Assembly. | Nichols, SL., et al. 2024. Viruses. 16: PMID: 38932107
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rtn-1/2 Antibody (4A69) | sc-71981 | 200 µg/ml | $322.00 | |||
Rtn-1/2 Antibody (4A69): m-IgG Fc BP-HRP Bundle | sc-537211 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rtn-1/2 Antibody (4A69): m-IgGκ BP-HRP Bundle | sc-534421 | 200 µg Ab; 40 µg BP | $361.00 | |||
Rtn-1/2 Antibody (4A69): m-IgG1 BP-HRP Bundle | sc-545081 | 200 µg Ab; 20 µg BP | $361.00 |