PSD-95 Antibody (7E3): sc-32290
- PSD-95 Antibody (7E3) is a mouse monoclonal IgG1 κ PSD-95 antibody, cited in 106 publications, provided at 200 µg/ml
- raised against purified recombinant PSD-95 of rat origin
- PSD-95 Antibody (7E3) is recommended for detection of PSD-95 of mouse, rat and human origin by WB, IP and IF
- Anti-PSD-95 Antibody (7E3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PSD-95 Antibody (7E3) for WB applications. These reagents are now offered in bundles with PSD-95 Antibody (7E3) (see ordering information below).
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PSD-95 Antibody (7E3) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSD-95 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-PSD-95 antibody (7E3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSD-95, also known as SAP 90, plays a crucial role in organizing synaptic signaling complexes and is essential for proper functioning of excitatory synapses. PSD-95 is primarily located at postsynaptic density of neurons, where PSD-95 interacts with various receptors and scaffolding proteins, facilitating clustering of glutamate receptors and other signaling molecules. This localization is vital for synaptic plasticity, a process that underlies learning and memory. PSD-95 forms complexes with other proteins, such as NMDA and AMPA receptors, underscoring PSD-95′s importance in modulating synaptic strength and transmission. Additionally, PSD-95′s interaction with proteins like tumor suppressor APC suggests a role in regulating cellular growth and signaling pathways, highlighting significance beyond synaptic function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSD-95 Antibody (7E3) References:
- Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution. | Stehle, T. and Schulz, GE. 1992. J Mol Biol. 224: 1127-41. PMID: 1314905
- The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. | Cho, KO., et al. 1992. Neuron. 9: 929-42. PMID: 1419001
- Tumor-suppressor genes of Drosophila melanogaster. | Gateff, E. and Mechler, BM. 1989. Crit Rev Oncog. 1: 221-45. PMID: 2518684
- PSD-95 protects synapses from β-amyloid. | Dore, K., et al. 2021. Cell Rep. 35: 109194. PMID: 34077732
- O-GlcNAcylation modulates liquid-liquid phase separation of SynGAP/PSD-95. | Lv, P., et al. 2022. Nat Chem. 14: 831-840. PMID: 35637289
- A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome. | Lau, KA., et al. 2023. Prog Neurobiol. 230: 102513. PMID: 37536482
- Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment. | Fadahunsi, N., et al. 2024. Sci Adv. 10: eadg2636. PMID: 38427737
- Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. | Müller, BM., et al. 1995. J Neurosci. 15: 2354-66. PMID: 7891172
- Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. | Lue, RA., et al. 1994. Proc Natl Acad Sci U S A. 91: 9818-22. PMID: 7937897
- ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions. | Woods, DF. and Bryant, PJ. 1993. Mech Dev. 44: 85-9. PMID: 8155583
- Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. | Matsumine, A., et al. 1996. Science. 272: 1020-3. PMID: 8638125
- Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein. | Makino, K., et al. 1997. Oncogene. 14: 2425-33. PMID: 9188857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSD-95 Antibody (7E3) | sc-32290 | 200 µg/ml | $322.00 | |||
PSD-95 Antibody (7E3): m-IgG Fc BP-HRP Bundle | sc-526673 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSD-95 Antibody (7E3): m-IgG1 BP-HRP Bundle | sc-532046 | 200 µg Ab; 20 µg BP | $361.00 | |||
PSD-95 Antibody (7E3) AC | sc-32290 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PSD-95 Antibody (7E3) HRP | sc-32290 HRP | 200 µg/ml | $322.00 | |||
PSD-95 Antibody (7E3) FITC | sc-32290 FITC | 200 µg/ml | $336.00 | |||
PSD-95 Antibody (7E3) PE | sc-32290 PE | 200 µg/ml | $349.00 | |||
PSD-95 Antibody (7E3) Alexa Fluor® 488 | sc-32290 AF488 | 200 µg/ml | $364.00 | |||
PSD-95 Antibody (7E3) Alexa Fluor® 546 | sc-32290 AF546 | 200 µg/ml | $364.00 | |||
PSD-95 Antibody (7E3) Alexa Fluor® 594 | sc-32290 AF594 | 200 µg/ml | $364.00 | |||
PSD-95 Antibody (7E3) Alexa Fluor® 647 | sc-32290 AF647 | 200 µg/ml | $364.00 | |||
PSD-95 Antibody (7E3) Alexa Fluor® 680 | sc-32290 AF680 | 200 µg/ml | $364.00 | |||
PSD-95 Antibody (7E3) Alexa Fluor® 790 | sc-32290 AF790 | 200 µg/ml | $364.00 |