PMP22 Antibody (B-6): sc-515280
- PMP22 Antibody (B-6) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 110-134 near the C-terminus of PMP22 of human origin
- recommended for detection of PMP22 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PMP22 Antibody (B-6) for WB applications. These reagents are now offered in bundles with PMP22 Antibody (B-6) (see ordering information below).
QUICK LINKS
PMP22 Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects PMP22 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PMP22, or peripheral myelin protein 22, is a crucial growth-regulated membrane protein predominantly expressed by Schwann cells, where PMP22 plays a vital role in the formation and maintenance of compact myelin in the peripheral nervous system. PMP22 is essential for proper functioning of peripheral nerves, as PMP22 contributes to the structural integrity of the myelin sheath, which insulates nerve fibers and facilitates efficient signal transmission. Mutations in the PMP22 gene, located on human chromosome 17p11.2, are associated with several neuropathies, including Charcot-Marie-Tooth disease and hereditary neuropathy with liability to pressure palsies, highlighting PMP22′s importance in both health and disease. Anti-PMP22 antibody (B-6) is an invaluable tool for researchers studying myelin-related disorders and the underlying mechanisms of peripheral nerve function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PMP22 Antibody (B-6) References:
- Comparison of a new pmp22 transgenic mouse line with other mouse models and human patients with CMT1A. | Robertson, AM., et al. 2002. J Anat. 200: 377-90. PMID: 12090404
- PMP22 expression in dermal nerve myelin from patients with CMT1A. | Katona, I., et al. 2009. Brain. 132: 1734-40. PMID: 19447823
- Abnormal junctions and permeability of myelin in PMP22-deficient nerves. | Guo, J., et al. 2014. Ann Neurol. 75: 255-65. PMID: 24339129
- Regulation of the neuropathy-associated Pmp22 gene by a distal super-enhancer. | Pantera, H., et al. 2018. Hum Mol Genet. 27: 2830-2839. PMID: 29771329
- Yield of the PMP22 deletion analysis in patients with compression neuropathies. | Ivanovic, V., et al. 2020. J Neurol. 267: 3617-3623. PMID: 32642785
- Direct relationship between increased expression and mistrafficking of the Charcot-Marie-Tooth-associated protein PMP22. | Marinko, JT., et al. 2020. J Biol Chem. 295: 11963-11970. PMID: 32647009
- Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22. | Marinko, JT., et al. 2021. J Biol Chem. 296: 100719. PMID: 33933451
- Dosage effects of PMP22 on nonmyelinating Schwann cells in hereditary neuropathy with liability to pressure palsies. | Koike, H., et al. 2022. Neuromuscul Disord. 32: 503-511. PMID: 35501275
- Young infants with PMP22 duplication can have minor nerve conduction study abnormalities. | Davion, JB., et al. 2022. Neurophysiol Clin. 52: 482-485. PMID: 36253232
- Electroceutical approach ameliorates intracellular PMP22 aggregation and promotes pro-myelinating pathways in a CMT1A in vitro model. | Intisar, A., et al. 2023. Biosens Bioelectron. 224: 115055. PMID: 36630746
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMP22 Antibody (B-6) | sc-515280 | 200 µg/ml | $322.00 | |||
PMP22 Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-541042 | 200 µg Ab; 10 µg BP | $361.00 | |||
PMP22 Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-542545 | 200 µg Ab; 20 µg BP | $361.00 | |||
PMP22 (B-6) Neutralizing Peptide | sc-515280 P | 100 µg/0.5 ml | $69.00 |