NFATc4 Antibody (A-2): sc-271127

NFATc4 Antibody (A-2) is a mouse monoclonal IgG2b antibody that detects NFATc4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NFATc4, or nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 4, is a crucial transcription factor that plays a significant role in regulating cytokine gene expression, particularly in T cells, where NFATc4 is essential for the inducible expression of cytokines like IL-2 and IL-4. NFATc4 is located primarily in the cytoplasm and translocates to the nucleus upon T cell receptor stimulation, a process that is vital for the activation of immune responses. This translocation is not only critical for T cell function but also influences various physiological processes, including cardiac hypertrophy and adipocyte differentiation. Additionally, NFATc4 is subject to post-translational modifications, such as phosphorylation by p38 MAP kinase, which modulates NFATc4 activity and stability, further underscoring NFATc4′s importance in cellular signaling pathways. Anti-NFATc4 antibody (A-2) is an invaluable tool for researchers studying immune responses and related signaling mechanisms in human cells.

The preferred NFATc4 antibody is NFATc4 Antibody (B-2): sc-271597.