MMP-7 Antibody (MM0022-4C21): sc-101566
- MMP-7 Antibody (MM0022-4C21) is a mouse monoclonal IgG2, cited in 3 publications, provided at 100 µg/ml
- raised against recombinant MMP-7 of human origin
- recommended for detection of MMP-7 of human origin by WB, IP, IF and IHC(P); non cross-reactive with other MMPs
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MMP-7 Antibody (MM0022-4C21). This work is in progress.
MMP-7 Antibody (MM0022-4C21) is a mouse monoclonal IgG2 antibody that detects MMP-7 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MMP-7, also known as Pump-1, matrilysin, or uterine metalloproteinase, plays a crucial role in the degradation of extracellular matrix components such as casein, fibronectin, and gelatin types I, III, IV, and V. MMP-7 is primarily produced by epithelial cells in mice, and expression is localized to specific organs, indicating involvement not only in matrix degradation and remodeling but also in the differentiated functions of these tissues. MMP-7 activity requires both calcium and zinc for catalytic function, and gene transcription can be activated by various stimuli, including phorbol ester, lipopolysaccharide, and staphylococcal enterotoxin B. Understanding MMP-7′s role in tissue homeostasis and pathology is essential, as dysregulation has been implicated in various diseases, including cancer and inflammatory conditions. Anti-MMP-7 antibody (MM0022-4C21) is an invaluable tool for researchers aiming to explore the functional dynamics of this important metalloproteinase in human health and disease.
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MMP-7 Antibody (MM0022-4C21) References:
- MT1-MMP and MMP-7 in invasion and metastasis of human cancers. | Shiomi, T. and Okada, Y. 2003. Cancer Metastasis Rev. 22: 145-52. PMID: 12784993
- Prognostic significance of MMP-7 expression in colorectal cancer: a meta-analysis. | Sun, DW., et al. 2015. Cancer Epidemiol. 39: 135-42. PMID: 25677090
- MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas. | Ahmed Haji Omar, A., et al. 2015. Oral Surg Oral Med Oral Pathol Oral Radiol. 119: 459-67. PMID: 25697929
- Role of MMP-2, MMP-7, MMP-9 and TIMP-2 in the development of recurrent depressive disorder. | Bobińska, K., et al. 2016. J Affect Disord. 205: 119-129. PMID: 27434116
- Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke. | Hsieh, FI., et al. 2019. J Clin Med. 8: PMID: 31752174
- The Behavior of MMP-2, MMP-7, MMP-9, and Their Inhibitors TIMP-1 and TIMP-2 in Adenoma-Colorectal Cancer Sequence. | Barabás, L., et al. 2021. Dig Dis. 39: 217-224. PMID: 32961536
- Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures. | Benkhalifa, M., et al. 2021. Zygote. 29: 365-371. PMID: 33736747
- Plasma Concentrations of Matrilysins MMP-7 and MMP-26 as Diagnostic Biomarkers in Breast Cancer. | Piskór, BM., et al. 2021. J Clin Med. 10: PMID: 33916127
- An Unexplored Role for MMP-7 (Matrix Metalloproteinase-7) in Promoting Gut Permeability After Ischemic Stroke. | Larochelle, J., et al. 2022. Stroke. 53: 3238-3242. PMID: 35904018
- Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children. | Yin, T., et al. 2024. BMC Surg. 24: 195. PMID: 38914992
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-7 Antibody (MM0022-4C21) | sc-101566 | 100 µg/ml | $322.00 |