KIR3DL1 Antibody (C-8): sc-514336
- KIR3DL1 Antibody (C-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 20-45 within an extracellular domain of KIR3DL1 of human origin
- recommended for detection of a broad range of KIR family members of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KIR3DL1 Antibody (C-8) for WB applications. These reagents are now offered in bundles with KIR3DL1 Antibody (C-8) (see ordering information below).
KIR3DL1 Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects KIR3DL1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KIR3DL1 plays a crucial role in the immune response by regulating the activity of natural killer (NK) cells, which are essential for the body′s defense against tumors and virally infected cells. This receptor specifically recognizes human leukocyte antigen (HLA) class I molecules, particularly those with the Bw4 allele, and transmits inhibitory signals that prevent NK cell-mediated cytotoxicity, thereby maintaining a balance between activation and inhibition of immune responses. KIR3DL1 is a type I transmembrane protein composed of 444 amino acids and features three immunoglobulin-like C2-type domains, which are vital for interaction with HLA molecules. Proper functioning of KIR3DL1 is important for preventing excessive immune activation that could lead to tissue damage, making KIR3DL1 a significant factor in both immune regulation and potential therapeutic targets in various diseases. Human KIR3DL1 is located on chromosome 19q13.4, highlighting genetic significance in the context of immune system function and disease susceptibility.
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KIR3DL1 Antibody (C-8) References:
- Both the nature of KIR3DL1 alleles and the KIR3DL1/S1 allele combination affect the KIR3DL1 NK-cell repertoire in the French population. | Gagne, K., et al. 2013. Eur J Immunol. 43: 1085-98. PMID: 23436464
- KIR3DS1-Specific D0 Domain Polymorphisms Disrupt KIR3DL1 Surface Expression and HLA Binding. | Mulrooney, TJ., et al. 2015. J Immunol. 195: 1242-50. PMID: 26109640
- KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. | Boudreau, JE., et al. 2016. J Immunol. 196: 3398-410. PMID: 26962229
- KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma. | Forlenza, CJ., et al. 2016. J Clin Oncol. 34: 2443-51. PMID: 27069083
- Evaluation of KIR3DL1/KIR3DS1 polymorphism in Behçet's disease. | Erer, B., et al. 2016. Genes Immun. 17: 396-399. PMID: 27708262
- CD8αα homodimers function as a coreceptor for KIR3DL1. | Geng, J. and Raghavan, M. 2019. Proc Natl Acad Sci U S A. 116: 17951-17956. PMID: 31420518
- Donor KIR3DL1/receptor HLA-Bw4-80I Combination Reduces Acute Leukemia Relapse after Umbilical Cord Blood Transplantation without in Vitro T-cell Depletion. | Fang, X., et al. 2021. Mediterr J Hematol Infect Dis. 13: e2021005. PMID: 33489044
- Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1. | Harrison, GF., et al. 2022. PLoS Comput Biol. 18: e1009059. PMID: 35192601
- Non-Expressed Donor KIR3DL1 Alleles May Represent a Risk Factor for Relapse after T-Replete Haploidentical Hematopoietic Stem Cell Transplantation. | Legrand, N., et al. 2023. Cancers (Basel). 15: PMID: 37345091
- Oncogenic alterations in KIR3DL1 in cutaneous acral CD8+ lymphoproliferative disorder. | Wobser, M., et al. 2024. Br J Dermatol. 191: 816-822. PMID: 38924750
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIR3DL1 Antibody (C-8) | sc-514336 | 200 µg/ml | $322.00 | |||
KIR3DL1 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-538628 | 200 µg Ab; 10 µg BP | $361.00 | |||
KIR3DL1 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-536274 | 200 µg Ab; 40 µg BP | $361.00 | |||
KIR3DL1 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-545799 | 200 µg Ab; 20 µg BP | $361.00 | |||
KIR3DL1 (C-8) Neutralizing Peptide | sc-514336 P | 100 µg/0.5 ml | $69.00 |