KIF2C Antibody (2488C3a): sc-81305

KIF2C Antibody (2488C3a) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIF2C protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-KIF2C antibody (2488C3a) is available as the non-conjugated format. Kinesin family member 2C (KIF2C), also known as mitotic centromere-associated kinesin (MCAK), plays a crucial role in regulating microtubule dynamics during cell division, which is essential for accurate chromosome segregation. KIF2C (2488C3a) antibody targets a protein primarily located in the cytoplasm and nucleus, where KIF2C associates with the centromere during early prophase and disassociates after telophase, ensuring proper chromosome alignment and separation. KIF2C is particularly abundant in thymus and testis, indicating importance in cellular processes related to these tissues, while showing lower expression in small intestine, mucosal lining of colon, and placenta. Human KIF2C is mapped to chromosome 1p34.1, highlighting genetic significance. KIF2C′s interaction with microtubules and other proteins involved in mitotic spindle assembly makes KIF2C vital for maintaining genomic stability, and dysregulation has been implicated in various cancers, suggesting potential as a therapeutic target.

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KIF2C Antibody (2488C3a) References:

1. The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends.  |  Hunter, AW., et al. 2003. Mol Cell. 11: 445-57. PMID: 12620232
2. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments.  |  Kline-Smith, SL., et al. 2004. Mol Biol Cell. 15: 1146-59. PMID: 14699064
3. MCAK associates with the tips of polymerizing microtubules.  |  Moore, AT., et al. 2005. J Cell Biol. 169: 391-7. PMID: 15883193
4. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.  |  Manning, AL., et al. 2007. Mol Biol Cell. 18: 2970-9. PMID: 17538014
5. Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis.  |  Shimo, A., et al. 2008. Cancer Sci. 99: 62-70. PMID: 17944972
6. MCAK associates with EB1.  |  Lee, T., et al. 2008. Oncogene. 27: 2494-500. PMID: 17968321
7. MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover.  |  Wordeman, L., et al. 2007. J Cell Biol. 179: 869-79. PMID: 18039936
8. KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.  |  Deng, H., et al. 2023. Mol Cell Probes. 72: 101938. PMID: 37863123
9. KIF2C: An important factor involved in signaling pathways, immune infiltration, and DNA damage repair in tumorigenesis.  |  Li, RQ., et al. 2024. Biomed Pharmacother. 171: 116173. PMID: 38237349
10. KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker.  |  Kreis, NN., et al. 2024. Crit Rev Clin Lab Sci. 61: 404-434. PMID: 38344808
11. Cloning and expression of human mitotic centromere-associated kinesin gene.  |  Kim, IG., et al. 1997. Biochim Biophys Acta. 1359: 181-6. PMID: 9434124
12. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation.  |  Maney, T., et al. 1998. J Cell Biol. 142: 787-801. PMID: 9700166

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIF2C Antibody (2488C3a) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-KIF2C Antibody (2488C3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIF2C Antibody (2488C3a) Specifications

Alternate Product Name: KIF2C

Product Clone Name: 2488C3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: KIF2C

Epitope Species: human

Product Reactivity/Detection: KIF2C

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for KIF2C Antibody (2488C3a): N/A