IRF-7 Antibody (3D9): sc-130509

IRF-7 Antibody (3D9) is a mouse monoclonal IgG1 antibody that detects interferon regulatory factor-7 (IRF-7) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IRF-7 plays a crucial role in the immune response by acting as a key transcription factor that regulates the expression of type I interferons, particularly interferon-α and interferon-β, which are vital for antiviral defense. Located primarily in the nucleus, IRF-7 is activated in response to viral infections and is essential for the induction of interferon-stimulated genes that help establish an antiviral state in cells. IRF-7′s ability to enhance the transcription of these genes underscores its importance in the innate immune response, as IRF-7 helps orchestrate the body′s defense mechanisms against pathogens. Additionally, IRF-7 is known to interact with various proteins, including IRF-3, which is another member of the interferon regulatory factor family, and together they can synergistically enhance the transcription of interferon genes. IRF-7 (3D9) antibody is an invaluable tool for researchers studying the molecular pathways of immune regulation and the mechanisms of viral pathogenesis.

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IRF-7 Antibody (3D9) References:

1. Multiple regulatory domains control IRF-7 activity in response to virus infection.  |  Lin, R., et al. 2000. J Biol Chem. 275: 34320-7. PMID: 10893229
2. The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7.  |  Xie, R., et al. 2001. J Biol Chem. 276: 18624-32. PMID: 11278666
3. Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes.  |  Barnes, BJ., et al. 2003. J Biol Chem. 278: 16630-41. PMID: 12600985
4. Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection.  |  Ousman, SS., et al. 2005. J Virol. 79: 7514-27. PMID: 15919906
5. Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages.  |  Romieu-Mourez, R., et al. 2006. Cancer Res. 66: 10576-85. PMID: 17079482
6. Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.  |  Daffis, S., et al. 2009. PLoS Pathog. 5: e1000607. PMID: 19798431
7. Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7.  |  Li, Y., et al. 2012. Mol Cell Biol. 32: 1164-72. PMID: 22252322
8. Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex.  |  Lee, HC., et al. 2014. J Biol Chem. 289: 5310-9. PMID: 24385435
9. IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice.  |  Spann, KM., et al. 2014. Am J Pathol. 184: 1795-806. PMID: 24726644
10. An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses.  |  Carlin, AF., et al. 2017. Cell Rep. 21: 1600-1612. PMID: 29117564

The preferred IRF-7 antibody is IRF-7 Antibody (G-8): sc-74472.