Molecular structure of GW3965
GW3965 (CAS 405911-09-3)
Alternate Names:
GW 3965A
CAS Number:
405911-09-3
Molecular Weight:
582.05
Molecular Formula:
C33H31ClF3NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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GW3965 is a compound extensively used in biological research, particularly for its ability to activate liver X receptors (LXRs). LXRs are nuclear receptors that play a role in the regulation of cholesterol, fatty acid, and glucose homeostasis. Studies involving GW3965 often focus on understanding the molecular pathways affected by LXR activation and how these pathways contribute to lipid metabolism. The compound is also used to investigate the role of LXRs in the expression of genes involved in lipid transport and inflammatory response. Additionally, GW3965 serves as a tool to explore the potential of LXR agonists in modulating the expression of ATP-binding cassette (ABC) transporters, which are critical for maintaining cellular lipid homeostasis.
GW3965 (CAS 405911-09-3) References
- GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. | Leik, CE., et al. 2007. Br J Pharmacol. 151: 450-6. PMID: 17420776
- Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages. | Wang, YY., et al. 2009. Shock. 32: 548-53. PMID: 19295476
- ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. | Donkin, JJ., et al. 2010. J Biol Chem. 285: 34144-54. PMID: 20739291
- The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1. | Stukas, S., et al. 2012. Biochim Biophys Acta. 1821: 536-46. PMID: 21889608
- The neurorestorative benefit of GW3965 treatment of stroke in mice. | Cui, X., et al. 2013. Stroke. 44: 153-61. PMID: 23204055
- The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. | Namjoshi, DR., et al. 2013. PLoS One. 8: e53529. PMID: 23349715
- LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice. | Archer, A., et al. 2013. J Lipid Res. 54: 1300-11. PMID: 23446231
- The LXR ligand GW3965 inhibits Newcastle disease virus infection by affecting cholesterol homeostasis. | Sheng, XX., et al. 2016. Arch Virol. 161: 2491-501. PMID: 27357231
- ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke. | Cui, X., et al. 2017. Stroke. 48: 459-467. PMID: 28028143
- Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-κB in vitro. | Hu, Y., et al. 2017. Oncotarget. 8: 15802-15814. PMID: 28178657
- Epithelial-to-mesenchymal transition correlates with gefitinib resistance in NSCLC cells and the liver X receptor ligand GW3965 reverses gefitinib resistance through inhibition of vimentin. | Hu, Y., et al. 2017. Onco Targets Ther. 10: 2341-2348. PMID: 28496332
- Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice. | Yu, M., et al. 2017. Adv Healthc Mater. 6: PMID: 28730752
- Liver X Receptor Agonist GW3965 Regulates Synaptic Function upon Amyloid Beta Exposure in Hippocampal Neurons. | Báez-Becerra, C., et al. 2018. Neurotox Res. 33: 569-579. PMID: 29297151
- The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta. | Han, S., et al. 2018. Life Sci. 213: 287-293. PMID: 30366037
- Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques. | Benne, N., et al. 2020. Adv Healthc Mater. 9: e2000043. PMID: 32329226
Inhibitor of:
KIAA1107, LRP2BP, ORP-8, RIP15, RLD-1, and S-100A5.Activator of:
AADACL3, ABC-A1, Angptl3, apoA, C20orf135, Ces1d, GRAMD1C, LXR, LXR alpha, NPC1, RIP15, RLD-1, and TBL1X.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW3965, 10 mg | sc-490151 | 10 mg | $260.00 | |||
GW3965, 50 mg | sc-490151A | 50 mg | $872.00 | |||
GW3965, 1 g | sc-490151B | 1 g | $1637.00 |