GSTO1/2 Antibody (H-12): sc-166121
- GSTO1/2 Antibody (H-12) is a mouse monoclonal IgG1 κ GSTO1/2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-241 representing full length GSTO1 of human origin
- GSTO1/2 Antibody (H-12) is recommended for detection of GSTO1 and GSTO2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GSTO1/2 Antibody (H-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GSTO1/2 Antibody (H-12) for WB applications. These reagents are now offered in bundles with GSTO1/2 Antibody (H-12) (see ordering information below).
GSTO1/2 Antibody (H-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects GSTO1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GSTO1/2 (H-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GSTO1 protein, also known as glutathione S-transferase omega 1, is a 241 amino acid protein primarily localized in the cytoplasm and features both an N-terminal and a C-terminal GST domain. GSTO1 is expressed ubiquitously, with highest levels found in the heart, liver, and skeletal muscle, and functions as a homodimer that plays a crucial role in detoxification processes. GSTO1 catalyzes the conjugation of glutathione to a wide range of organic compounds, forming thioethers vital for metabolism and detoxification of xenobiotics and carcinogens. GSTO1 polymorphisms have been linked to childhood acute lymphoblastic leukemia, Parkinson′s disease, and Alzheimer′s disease. GSTO2, closely related to GSTO1, is expressed in various tissues and contributes to the conversion of reactive compounds and glutathione, highlighting this protein family′s functional significance in cellular defense mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GSTO1/2 Antibody (H-12) References:
- Identification, characterization, and crystal structure of the Omega class glutathione transferases. | Board, PG., et al. 2000. J Biol Chem. 275: 24798-806. PMID: 10783391
- Immunohistochemistry of omega class glutathione S-transferase in human tissues. | Yin, ZL., et al. 2001. J Histochem Cytochem. 49: 983-7. PMID: 11457926
- Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. | Whitbread, AK., et al. 2003. Pharmacogenetics. 13: 131-44. PMID: 12618591
- Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. | Li, YJ., et al. 2003. Hum Mol Genet. 12: 3259-67. PMID: 14570706
- Glutathione transferase Omega class polymorphisms in Parkinson disease. | Whitbread, AK., et al. 2004. Neurology. 62: 1910-1. PMID: 15159516
- Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. | Wahner, AD., et al. 2007. Neurosci Lett. 413: 274-8. PMID: 17194543
- Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase. | Ishikawa, T., et al. 1998. J Biol Chem. 273: 28708-12. PMID: 9786866
- The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins. | Kodym, R., et al. 1999. J Biol Chem. 274: 5131-7. PMID: 9988762
- Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia. | Pongstaporn, W., et al. 2009. J Cancer Res Clin Oncol. 135: 673-8. PMID: 18941778
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSTO1/2 Antibody (H-12) | sc-166121 | 200 µg/ml | $322.00 | |||
GSTO1/2 Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-528911 | 200 µg Ab; 10 µg BP | $361.00 | |||
GSTO1/2 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-521515 | 200 µg Ab, 40 µg BP | $361.00 | |||
GSTO1/2 Antibody (H-12): m-IgG1 BP-HRP Bundle | sc-543206 | 200 µg Ab; 20 µg BP | $361.00 | |||
GSTO1/2 Antibody (H-12) AC | sc-166121 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GSTO1/2 Antibody (H-12) HRP | sc-166121 HRP | 200 µg/ml | $322.00 | |||
GSTO1/2 Antibody (H-12) FITC | sc-166121 FITC | 200 µg/ml | $336.00 | |||
GSTO1/2 Antibody (H-12) PE | sc-166121 PE | 200 µg/ml | $349.00 | |||
GSTO1/2 Antibody (H-12) Alexa Fluor® 488 | sc-166121 AF488 | 200 µg/ml | $364.00 | |||
GSTO1/2 Antibody (H-12) Alexa Fluor® 546 | sc-166121 AF546 | 200 µg/ml | $364.00 | |||
GSTO1/2 Antibody (H-12) Alexa Fluor® 594 | sc-166121 AF594 | 200 µg/ml | $364.00 | |||
GSTO1/2 Antibody (H-12) Alexa Fluor® 647 | sc-166121 AF647 | 200 µg/ml | $364.00 | |||
GSTO1/2 Antibody (H-12) Alexa Fluor® 680 | sc-166121 AF680 | 200 µg/ml | $364.00 | |||
GSTO1/2 Antibody (H-12) Alexa Fluor® 790 | sc-166121 AF790 | 200 µg/ml | $364.00 |