m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for GAS41 Antibody (C-10) for WB applications. This reagent is now offered in a bundle with GAS41 Antibody (C-10) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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GAS41 Antibody (C-10) is a high quality monoclonal GAS41 antibody (also designated GAS41 antibody) suitable for the detection of the GAS41 protein of mouse, rat and human origin. GAS41 Antibody (C-10) is available as both the non-conjugated anti-GAS41 antibody form, as well as multiple conjugated forms of anti-GAS41 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Gene amplification is associated with tumor stage and progression in human gliomas. Several amplified loci are identified and comprise multiple genes. The glioma amplified sequence 41 (GAS41) is an evolutionarily conserved eukaryotic protein found in diverse species. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors in some acute leukemias, and interacts with a component of the nuclear matrix, NuMA, in interphase cells. GAS41 has a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. GAS41 is ubiquitously expressed, with the highest levels of expression in human brain. In neuroblastoma, GAS41 is located in the nucleoli, but not in the nucleoplasm. GAS41 also binds to the MLL fusion partner AF10, which is involved in two distinct chromosomal translocations associated with hematologic malignancy. In addition, GAS41 interacts with INI1 (Integrase Interactor), which is a human homologue of the yeast SNF5 protein, a component of the SWI/SNF complex. The GAS41 gene maps to human chromosome 12q15.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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