Filamin 1 Antibody (PM6/317): sc-58764
- Filamin 1 Antibody (PM6/317) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against full length platelet Filamin 1 of human origin
- recommended for detection of Filamin 1 from platelets, lymphocytes, fibroblasts and smooth muscle of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Filamin 1 (E-3): sc-17749 for Filamin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Filamin 1 Antibody (PM6/317) for WB and IHC(P) applications. These reagents are now offered in bundles with Filamin 1 Antibody (PM6/317) (see ordering information below).
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Filamin 1 Antibody (PM6/317) is a mouse monoclonal IgG1 antibody that detects Filamin 1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Filamin 1 plays a crucial role in maintaining the structural integrity of the cytoskeleton by crosslinking actin filaments into a three-dimensional network, which is essential for cellular shape, motility, and mechanical stability. Filamin 1 is predominantly located in the cytoplasm and exists as a homodimer, allowing effective organization of actin filaments in response to cellular signals. Anti-Filamin 1 antibody (PM6/317) enables researchers to study crucial cellular processes, including cell migration and division, where Filamin 1 dysregulation has been implicated in several diseases, including cancer and cardiovascular disorders. Filamin 1 (PM6/317) antibody serves as an invaluable tool for studying cytoskeleton dynamics and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Filamin 1 Antibody (PM6/317) References:
- [Filamin A as a mediator of alterations in cancer cells]. | Wieczorek, K. and Niewiarowska, J. 2014. Postepy Biochem. 60: 77-83. PMID: 25033545
- Filamin A and DRD2 expression in corticotrophinomas. | Sickler, T., et al. 2019. Pituitary. 22: 163-169. PMID: 30799513
- Filamin A and parafibromin expression in parathyroid carcinoma. | Storvall, S., et al. 2021. Eur J Endocrinol. 185: 803-812. PMID: 34606470
- Filamin-A expression in laryngeal squamous cell carcinoma and its clinical significance. | Ouban, A. 2022. Histol Histopathol. 37: 125-136. PMID: 34677823
- Deficiency of filamin A in smooth muscle cells protects against hypoxia‑mediated pulmonary hypertension in mice. | Zheng, Y., et al. 2023. Int J Mol Med. 51: PMID: 36704846
- The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation. | Feng, Z., et al. 2023. J Cell Sci. 136: PMID: 36806943
- Importance of the filamin A-Sav1 interaction in organ size control: evidence from transgenic mice. | Zhang, H., et al. 2023. Int J Dev Biol. 67: 27-37. PMID: 37548015
- Long-chain noncoding RNA LINC01569 upregulates filamin A-interacting protein 1-like to prevent metastasis of triple-negative breast cancer via sponging miR-300. | Jiang, X., et al. 2024. Cancer Biomark. 39: 79-94. PMID: 37955081
- Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression. | Vitali, E., et al. 2024. Liver Int. 44: 518-531. PMID: 38010911
- Filamin A heart valve disease as a genetic cause of inherited bicuspid and tricuspid aortic valve disease. | Delwarde, C., et al. 2024. Heart. 110: 666-674. PMID: 38148157
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Filamin 1 Antibody (PM6/317) | sc-58764 | 200 µg/ml | $322.00 | |||
Filamin 1 Antibody (PM6/317): m-IgG Fc BP-HRP Bundle | sc-539098 | 200 µg Ab; 10 µg BP | $361.00 | |||
Filamin 1 Antibody (PM6/317): m-IgG1 BP-HRP Bundle | sc-541257 | 200 µg Ab; 20 µg BP | $361.00 |