Filamin 1 Antibody (FLMN01): sc-58763
- Filamin 1 Antibody (FLMN01) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against full length platelet Filamin 1 of human origin
- recommended for detection of Filamin 1 from platelets, lymphocytes, fibroblasts and smooth muscle of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Filamin 1 (E-3): sc-17749 for Filamin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Filamin 1 Antibody (FLMN01) for WB and IHC(P) applications. These reagents are now offered in bundles with Filamin 1 Antibody (FLMN01) (see ordering information below).
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Filamin 1 Antibody (FLMN01) is a mouse monoclonal IgG1 antibody that detects Filamin 1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Filamin 1 plays a crucial role in organizing the cytoskeleton by crosslinking actin filaments into a three-dimensional network, which maintains cell shape, enables cellular movement, and facilitates intracellular transport. Filamin 1 functions extend to mechanotransduction and signal transduction pathways, which are vital for cellular responses to mechanical stimuli and external signals. Filamin 1 interacts with numerous proteins, including integrins and growth factor receptors, influencing cell adhesion and migration. Filamin 1′s ability to form homodimers enhances structural integrity and functional versatility, making Filamin 1 a key player in both muscle and non-muscle tissues. With diverse roles and interactions, Filamin 1 remains significant for researchers studying cytoskeletal dynamics and cellular behavior.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Filamin 1 Antibody (FLMN01) References:
- FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans. | Kovacevic, I. and Cram, EJ. 2010. Dev Biol. 347: 247-57. PMID: 20707996
- [Filamin A as a mediator of alterations in cancer cells]. | Wieczorek, K. and Niewiarowska, J. 2014. Postepy Biochem. 60: 77-83. PMID: 25033545
- Filamin A: Insights into its Exact Role in Cancers. | Shao, QQ., et al. 2016. Pathol Oncol Res. 22: 245-52. PMID: 26341089
- Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression. | Dotson, D., et al. 2016. J Biol Chem. 291: 4236-46. PMID: 26742839
- Filamin A modulates platelet function. | Lopez, JJ., et al. 2018. Aging (Albany NY). 10: 3052-3053. PMID: 30401791
- Filamin A: key actor in platelet biology. | Rosa, JP., et al. 2019. Blood. 134: 1279-1288. PMID: 31471375
- FLN-1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue. | Kelley, CA., et al. 2020. Cytoskeleton (Hoboken). 77: 379-398. PMID: 32969593
- Filamin A Regulates Cardiovascular Remodeling. | Bandaru, S., et al. 2021. Int J Mol Sci. 22: PMID: 34207234
- Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress. | Grande, V., et al. 2023. Cell Tissue Res. 393: 133-147. PMID: 37178194
- Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression. | Vitali, E., et al. 2024. Liver Int. 44: 518-531. PMID: 38010911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Filamin 1 Antibody (FLMN01) | sc-58763 | 200 µg/ml | $322.00 | |||
Filamin 1 Antibody (FLMN01): m-IgG Fc BP-HRP Bundle | sc-539097 | 200 µg Ab; 10 µg BP | $361.00 | |||
Filamin 1 Antibody (FLMN01): m-IgG1 BP-HRP Bundle | sc-541256 | 200 µg Ab; 20 µg BP | $361.00 |