Filamin 1 Antibody (3F180): sc-71118
- Filamin 1 Antibody (3F180) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length platelet Filamin 1 of human origin
- recommended for detection of Filamin 1 from platelets, lymphocytes, fibroblasts and smooth muscle of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Filamin 1 (E-3): sc-17749 for Filamin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Filamin 1 Antibody (3F180) for WB and IHC(P) applications. These reagents are now offered in bundles with Filamin 1 Antibody (3F180) (see ordering information below).
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Filamin 1 Antibody (3F180) is a mouse monoclonal IgG1 antibody that detects Filamin 1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Filamin 1 is a crucial actin-binding protein that plays a significant role in maintaining the structural integrity of the cytoskeleton by crosslinking actin filaments into a three-dimensional network, which is essential for cellular shape, motility, and mechanical stability. Filamin 1 is predominantly found in the cytoplasm, where Filamin 1 forms homodimers that facilitate the organization of actin filaments, thereby influencing cell signaling and migration. Proper functioning of Filamin 1 is vital for various cellular processes, including the maintenance of cell shape and the regulation of cell adhesion, which are critical for tissue integrity and function. Dysregulation of Filamin 1 has been implicated in several diseases, including cancer and cardiovascular disorders, highlighting Filamin 1′s importance as a target for therapeutic intervention. Anti-Filamin 1 antibody (3F180) provides a reliable tool for researchers aiming to explore the dynamics of actin cytoskeleton organization and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Filamin 1 Antibody (3F180) References:
- [Filamin A as a mediator of alterations in cancer cells]. | Wieczorek, K. and Niewiarowska, J. 2014. Postepy Biochem. 60: 77-83. PMID: 25033545
- Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression. | Dotson, D., et al. 2016. J Biol Chem. 291: 4236-46. PMID: 26742839
- Filamin A modulates platelet function. | Lopez, JJ., et al. 2018. Aging (Albany NY). 10: 3052-3053. PMID: 30401791
- Filamin A: key actor in platelet biology. | Rosa, JP., et al. 2019. Blood. 134: 1279-1288. PMID: 31471375
- The function and pathogenic mechanism of filamin A. | Zhou, J., et al. 2021. Gene. 784: 145575. PMID: 33737122
- Filamin A Regulates Cardiovascular Remodeling. | Bandaru, S., et al. 2021. Int J Mol Sci. 22: PMID: 34207234
- Filamin-A expression in laryngeal squamous cell carcinoma and its clinical significance. | Ouban, A. 2022. Histol Histopathol. 37: 125-136. PMID: 34677823
- Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress. | Grande, V., et al. 2023. Cell Tissue Res. 393: 133-147. PMID: 37178194
- Importance of the filamin A-Sav1 interaction in organ size control: evidence from transgenic mice. | Zhang, H., et al. 2023. Int J Dev Biol. 67: 27-37. PMID: 37548015
- Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression. | Vitali, E., et al. 2024. Liver Int. 44: 518-531. PMID: 38010911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Filamin 1 Antibody (3F180) | sc-71118 | 200 µg/ml | $322.00 | |||
Filamin 1 Antibody (3F180): m-IgG Fc BP-HRP Bundle | sc-539348 | 200 µg Ab; 10 µg BP | $361.00 | |||
Filamin 1 Antibody (3F180): m-IgG1 BP-HRP Bundle | sc-541429 | 200 µg Ab; 20 µg BP | $361.00 |