Fibronectin Antibody (IST-1): sc-59824

Fibronectin Antibody (IST-1) is a mouse monoclonal IgG1 antibody that detects Fibronectin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Fibronectin is a crucial extracellular matrix glycoprotein that plays a significant role in cell adhesion, motility, and wound healing, making Fibronectin essential for tissue repair and regeneration. Fibronectin exists as a high molecular weight heterodimer, and Fibronectin′s presence on cell surfaces and in extracellular fluids is vital for maintaining cellular architecture and function. Notably, Fibronectin undergoes post-translational modifications such as glycosylation, which can influence Fibronectin′s interaction with other proteins and functional properties. For instance, glycosylated forms of Fibronectin have been implicated in the formation of the myofibroblast phenotype, particularly in conditions like Dupuytren′s disease, where specific splice variants of Fibronectin are associated with pathological tissue remodeling. Anti-Fibronectin antibody (IST-1) is therefore an invaluable tool for researchers studying the dynamics of extracellular matrix components and their roles in health and disease.

The preferred Fibronectin antibody is Fibronectin Antibody (EP5): sc-8422.