ERAB Antibody (F-1): sc-393694

ERAB Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects ERAB in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERAB, or endoplasmic reticulum-associated β-Amyloid-binding protein, plays a crucial role in the cellular response to β-Amyloid, a neurotoxic peptide linked to Alzheimer′s disease. ERAB is primarily located in the endoplasmic reticulum, where ERAB is involved in the regulation of cellular stress responses. The localization of ERAB is significant because ERAB allows for the modulation of calcium homeostasis and the management of oxidative stress, both of which are critical in maintaining neuronal health. In the context of Alzheimer′s disease, the interaction between β-Amyloid and ERAB leads to increased neuronal vulnerability, highlighting ERAB′s importance in neuroprotection. By understanding the cellular dynamics of ERAB, researchers can explore potential therapeutic strategies aimed at mitigating the neurotoxic effects of β-Amyloid, making anti-ERAB antibody (F-1) an essential tool for studying these complex interactions in neurodegenerative research.

The preferred ERAB antibody is ERAB Antibody (E-10): sc-393693.