DDX56 Antibody (F-3): sc-393077

DDX56 Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects DDX56 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDX56, also known as DDX21 or NOH61, plays a crucial role in ribosome synthesis, particularly during the assembly of the large 60S ribosomal subunit, which is essential for protein translation and overall cellular function. The proper assembly of ribosomes is vital for maintaining cellular homeostasis and facilitating the synthesis of proteins that are necessary for various biological processes, including cell growth and division. DDX56 contains a helicase core region, a leucine zipper motif at its N-terminus, and two putative C-terminal nuclear localization signals, which are important for its function and localization within the cell. Additionally, the presence of several potential phosphorylation sites suggests that DDX56 may be regulated by post-translational modifications, further underscoring its significance in cellular dynamics. Anti-DDX56 antibody (F-3) is an invaluable tool for researchers studying ribosome assembly and related cellular processes.

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DDX56 Antibody (F-3) References:

1. The capsid-binding nucleolar helicase DDX56 is important for infectivity of West Nile virus.  |  Xu, Z., et al. 2011. J Virol. 85: 5571-80. PMID: 21411523
2. The helicase activity of DDX56 is required for its role in assembly of infectious West Nile virus particles.  |  Xu, Z. and Hobman, TC. 2012. Virology. 433: 226-35. PMID: 22925334
3. Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer.  |  Kouyama, Y., et al. 2019. Cancer Sci. 110: 3132-3144. PMID: 31390121
4. Correction: DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.  |  Li, D., et al. 2020. J Cell Sci. 133: PMID: 32079732
5. Integrated Analysis of DEAD-Box Helicase 56: A Potential Oncogene in Osteosarcoma.  |  Zhu, C., et al. 2020. Front Bioeng Biotechnol. 8: 588. PMID: 32671031
6. RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis.  |  Moudry, P., et al. 2022. Cell Death Differ. 29: 687-696. PMID: 34611297
7. DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.  |  Wang, J., et al. 2022. Bioengineered. 13: 13970-13985. PMID: 35723050
8. DExH/D-box helicases at the frontline of intrinsic and innate immunity against viral infections.  |  Bonaventure, B. and Goujon, C. 2022. J Gen Virol. 103: PMID: 36006669
9. Identification and Validation in a Novel Classification of Helicase Patterns for the Prediction of Tumor Proliferation and Prognosis.  |  Yin, Y., et al. 2022. J Hepatocell Carcinoma. 9: 885-900. PMID: 36061235
10. High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma.  |  Tao, S., et al. 2024. BMC Cancer. 24: 194. PMID: 38347489

The preferred DDX56 antibody is DDX56 Antibody (F-5): sc-393078.