CD3-ε Antibody (LE-CD3): sc-69733

CD3-ε Antibody (LE-CD3) is a mouse monoclonal IgG1 antibody that detects CD3-ε in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CD3-ε is a crucial component of the T cell antigen receptor (TCR) complex, playing a vital role in T cell activation and signaling. CD3-ε forms a heterodimer with CD3-γ and is essential for the transduction of signals that lead to T cell proliferation and differentiation upon antigen recognition. The presence of CD3-ε in the TCR complex is significant because CD3-ε contains an immunoreceptor tyrosine-based activation motif (ITAM) that is critical for initiating downstream signaling cascades. This motif is phosphorylated upon TCR engagement, creating docking sites for various signaling proteins, including ZAP-70, which further propagate the activation signal within the T cell. The interaction of CD3-ε with other proteins in the signaling pathway underscores CD3-ε′s importance in immune responses, making CD3-ε a valuable target for research in immunology and therapeutic applications. Anti-CD3-ε antibody (LE-CD3) is therefore an essential tool for studying T cell biology and the mechanisms underlying immune activation.

The preferred CD3-ε antibody is CD3-ε Antibody (UCH-T1): sc-1179.