beta-catenin Antibody (6F9): sc-53484

β-catenin Antibody (6F9) is a mouse monoclonal IgG1 kappa light chain antibody developed against recombinant full-length β-catenin of chicken origin. β-catenin monoclonal antibody (6F9) effectively detects β-catenin from human, mouse, rat, avian, bovine, and canine sources across various applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), without cross-reactivity to plakoglobin. Available in non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, anti-β-catenin antibody (6F9) offers versatile solutions for diverse experimental needs. β-Catenin, also known as catenin beta-1 or CTNNB1, is a multifunctional protein integral to cell-cell adhesion and gene transcription regulation. Structurally, β-catenin comprises a central core of 12 armadillo repeats, which form a superhelical structure facilitating interactions with various binding partners, including cadherins and transcription factors. This structural configuration is crucial for β-catenin′s dual role: at the plasma membrane, β-catenin binds to the intracellular domain of cadherins, forming catenin-cadherin complexes essential for maintaining cellular adhesion and tissue architecture. In the nucleus, β-catenin interacts with TCF/LEF transcription factors to regulate gene expression involved in cell proliferation and differentiation. Dysregulation of β-catenin′s structure or localization can lead to various pathologies, including cancer, underscoring the importance of β-catenin′s structural integrity. β-catenin monoclonal antibody (6F9) is an indispensable tool for researchers investigating these critical cellular processes.

The preferred beta-catenin antibody is beta-catenin Antibody (E-5): sc-7963.